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First total synthesis of a naturally occurring nucleoside disulfide: 9-(5′-Deoxy-5′-thio-β-d-xylofuranosyl)adenine disulfide
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2012-09-01 , DOI: 10.1016/j.cclet.2012.06.011
Hai Xin Ding , Ling Cui Da , Ru Chun Yang , Ban Peng Cao , Qi Sun , Qiang Xiao

A naturally occurring nucleoside disulfide, 9-(5′-deoxy-5′-thio-β-d-xylofuranosyl)adenine disulfide, was first synthesized from d-xylose over 7 steps in 20% overall yield. The key step involved Vorbruggen glycosylation of silylated N6-benzoyladenine with xylose diacetate moiety.

中文翻译:

天然存在的核苷二硫化物的首次全合成:9-(5'-Deoxy-5'-thio-β-d-xylofuranosyl)腺嘌呤二硫化物

天然存在的核苷二硫化物9-(5'-脱氧-5'-硫代-β-d-呋喃呋喃糖基)腺嘌呤二硫化物首先由d-木糖经7个步骤合成,总产率为20%。关键步骤涉及甲硅烷基化的N6-苯甲酰腺嘌呤与木糖二乙酸酯部分的Vorbruggen糖基化。
更新日期:2012-09-01
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