Abstract A series of novel 2,4-diamino-pteridines ( 9a–l ) were synthesized and evaluated as inhibitors of inducible nitric oxide synthase (iNOS) in vitro . It was found that 9a , 9d , 9e , 9h , 9i and 9l showed potent inhibitory activities similar to that of methotrexate (MTX), while the activities of 9b , 9c , 9f , 9 g , 9j and 9k are stronger than MTX.

中文翻译：

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一氧化氮合酶抑制剂2,4-二氨基蝶啶衍生物的合成及生物学评价

摘要合成了一系列新颖的2,4-二氨基-哌啶类化合物（9a–l），并在体外作为诱导型一氧化氮合酶（iNOS）的抑制剂进行了评估。发现9a，9d，9e，9h，9i和9l表现出与甲氨蝶呤（MTX）相似的有效抑制活性，而9b，9c，9f，9g，9j和9k的抑制作用强于MTX。