Abstract In order to find novel leading structures of pesticide, a series of N-(pyrimidin-5-yl)-N′-phenylureas (4a–4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV (tobacco mosaic virus) activity. Two compounds (4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0 × 10−4 g/mL.

中文翻译：

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新型N-（嘧啶-5-基）-N'-苯基脲的合成及抗TMV活性

摘要为了寻找农药的新型主导结构，设计了一系列N-（嘧啶-5-基）-N'-苯基脲（4a–4h），并由4-氯-2-二乙基氨基-6-甲基- 5-硝基嘧啶1通过取代，还原和酰化步骤。初步生物测定表明，所有目标化合物均具有良好的抗TMV（烟草花叶病毒）活性。在5.0×10-4 g / mL的浓度下，两种化合物（4d和4e）显示出比病毒唑更高的活性。