Abstract As a highly strained small molecule, [1.1.1]-propellane has been widely used in various synthetic transformations owing to the exceptional reactivity of the central bond between the two bridgehead carbons. Utilizing strain-release approaches, the rapid development of strategies for the construction of bicyclo[1.1.1]pentane (BCP) and cyclobutane derivatives using [1.1.1]-propellane as the starting material has been witnessed in the past few years. In this review, we highlight the most recent advances in this field. Accordingly, the reactivity of [1.1.1]-propellane can be divided into three pathways, including radical, anionic and transition metal-catalyzed pathways under appropriateconditions.

中文翻译：

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[1.1.1]-丙炔在有机合成中的最新应用进展

摘要[1.1.1]-丙炔作为一种高应变小分子，由于两个桥头碳原子之间的中心键具有出色的反应活性，已被广泛用于各种合成转化中。利用应变释放方法，在过去几年中，目睹了以[1.1.1]-丙炔为起始原料构建双环[1.1.1]戊烷（BCP）和环丁烷衍生物的策略的快速发展。在本文中，我们重点介绍了该领域的最新进展。因此，在适当条件下，[1.1.1]-丙炔的反应性可分为三种途径，包括自由基，阴离子和过渡金属催化的途径。