Abstract A palladium-catalyzed [4 + 1] cycloaddition of prop-2-yn-1-ones with double isocyanides is developed herein. The transformation worked well to produce a series of 2-amino-4-cyanofurans with high efficiency and a broad reaction scope. Based on mechanism studies, it is believed that the palladium-catalyzed [4 + 1] imidoylative cycloaddition of prop-2-yn-1-ones was concerted. Treated with aryl amine and H2O, the [4 + 1] cycloaddition of prop-2-yn-1-ones with double isocyanides provided 2-amino-4-amidylpyrroles efficiently.

中文翻译：

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钯催化的prop-2-yn-1-one和异氰酸酯协同[4 +1]环化

摘要本文研究了丙-2-炔-1-酮与双异氰酸酯的钯催化[4 +1]环加成反应。该转化很好地生产了一系列高效且反应范围广的2-氨基-4-氰呋喃。基于机理研究，据信prop-2-yn-1-one的钯催化的[4 +1]酰亚胺化环加成反应是一致的。用芳基胺和H2O处理后，丙-2-炔-1-酮与双异氰酸酯的[4 +1]环加成反应有效地提供了2-氨基-4-酰胺基吡咯。