Nanoparticle surface property is crucial for circulation stability, cellullar uptake and other biological characteristics. Zwitterionic pillar[n]arenes (ZPns) were used to coat gold nanoparticles (GNPs) via host-guest interaction. The resulting GNPs demonstrated higher stability in blood serum compared to polyethylene glycol (PEG)-coated GNPs. ZPn-coated GNPs were responsive to UV-irradiation, competitive displacement and acidic pH. UV-irradiation or competitive displacement could lead to the removal of ZPn coating to expose GNPs, which enhanced cell uptake efficiency by 5.9- and 7.4-fold, respectively.

中文翻译：

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两性离子柱[n]芳烃包覆的超稳定和多刺激响应纳米颗粒，可增强细胞摄取

纳米颗粒的表面性质对于循环稳定性，细胞吸收和其他生物学特性至关重要。两性离子柱芳烃（ZP n s）用于通过宿主-客体相互作用涂覆金纳米颗粒（GNP）。与聚乙二醇（PEG）涂层的GNP相比，所得的GNP在血清中具有更高的稳定性。ZP n涂层的GNP对紫外线辐射，竞争性置换和酸性pH值有响应。紫外线照射或竞争性置换可能导致去除ZP n涂层以暴露GNP，从而使细胞摄取效率分别提高5.9倍和7.4倍。