1H-Indole-3-carboxaldehyde and its derivatives have represented the key intermediates for the preparation of biologically active compounds as well indole alkaloids. Also they are important precursors for the synthesis of divers heterocyclic derivatives because their carbonyl groups facilely undergo C–C and C–N coupling reactions and reductions. This review highlights the recent advances in 1H-indole-3-carboxaldhyde chemistry via discussing different synthetic procedures developed for the preparation of its derivatives, as well sheds the light on the most common reactions of 1H-indole-3-carboxaldhyde derivatives and exploitation of these derivatives as the blocks of many biologically active compounds.

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1H-吲哚-3-甲醛：合成与反应

1H-吲哚-3-甲醛及其衍生物已成为制备生物活性化合物以及吲哚生物碱的关键中间体。它们也是合成杂环杂环衍生物的重要前体，因为它们的羰基容易进行C–C和C–N偶联反应和还原。这篇综述通过讨论为制备其衍生物而开发的不同合成方法，突出了1H-吲哚-3-羧醛化学的最新进展，并阐明了1H-吲哚-3-羧醛衍生物的最常见反应和对1H-吲哚-3-羧醛的开发。这些衍生物是许多生物活性化合物的嵌段。