Difluoromethylation of 2-hydroxychalcones using sodium 2-chloro-2,2-difluoroacetate as the difluoromethylating agent was developed. Under facile conditions, a wide range of aryl difluoromethyl ethers were obtained in yields of 36%–80%. It is noteworthy that the new addition products, 2,2-difluoro-2H-benzofuran derivatives, were also synthesized in the reactions. The yield of 2,2-difluoro-2H-benzofuran derivative could be up to 35% when 3-methyl-2-hydroxychalcone was used as the reactant. A plausible reaction mechanism was proposed.

中文翻译：

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以2-氯-2,2-二氟乙酸钠为二氟甲基化剂，对2-羟基查尔酮进行二氟甲基化

开发了使用2-氯-2，2-二氟乙酸钠作为二氟甲基化剂的2-羟基查耳酮的二氟甲基化。在方便的条件下，获得了多种芳基二氟甲基醚，产率为36％–80％。值得注意的是，在该反应中还合成了新的加成产物2，2-二氟-2H-苯并呋喃衍生物。当将3-甲基-2-羟基查耳酮用作反应物时，2，2-二氟-2H-苯并呋喃衍生物的产率可高达35％。提出了合理的反应机理。