An efficient, atom-economic and green approach to synthesizing enamines was developed by intermolecular hydroamination of activated alkynes with high yields under catalyst- and solvent-free conditions. β-Dimethylamino-acrylate derivatives were also obtained with high yields. In the synthetic process of the derivatives, N,N-dimethylformamide(DMF) pretreated with metal Na, was used as reactant instead of dimethylamine gas. The proposed synthetic method can be used for the synthesis of (E)-ethyl-3-(dimethylamino)acrylate(3cl), and provide a new possible way to the synthesis of Quinolones.

中文翻译：

---

通过活化炔烃的分子间加氢胺化反应合成烯胺的高效绿色方法

通过在无催化剂和无溶剂条件下以高收率分子间氢化胺化炔烃，开发了一种高效，原子经济，绿色的烯胺合成方法。还以高收率获得了β-二甲基氨基丙烯酸酯衍生物。在衍生物的合成过程中，用金属Na预处理的N，N-二甲基甲酰胺（DMF）代替了二甲胺气体作为反应物。所提出的合成方法可用于合成（E）-乙基-3-（二甲基氨基）丙烯酸酯（3cl），为合成喹诺酮提供了一种新的可能途径。