当前位置：
X-MOL 学术
›
Environ. Sci. Technol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Lifetime Accumulation of Microplastic in Children and Adults
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-03-16 , DOI: 10.1021/acs.est.0c07384 Nur Hazimah Mohamed Nor 1 , Merel Kooi 1 , Noël J. Diepens 1 , Albert A. Koelmans 1
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-03-16 , DOI: 10.1021/acs.est.0c07384 Nur Hazimah Mohamed Nor 1 , Merel Kooi 1 , Noël J. Diepens 1 , Albert A. Koelmans 1
Affiliation
|
Human exposure to microplastic is recognized as a global problem, but the uncertainty, variability, and lifetime accumulation are unresolved. We provide a probabilistic lifetime exposure model for children and adults, which accounts for intake via eight food types and inhalation, intestinal absorption, biliary excretion, and plastic-associated chemical exposure via a physiologically based pharmacokinetic submodel. The model probabilistically simulates microplastic concentrations in the gut, body tissue, and stool, the latter allowing validation against empirical data. Rescaling methods were used to ensure comparability between microplastic abundance data. Microplastic (1–5000 μm) median intake rates are 553 particles/capita/day (184 ng/capita/day) and 883 particles/capita/day (583 ng/capita/day) for children and adults, respectively. This intake can irreversibly accumulate to 8.32 × 103 (90% CI, 7.08 × 102–1.91 × 106) particles/capita or 6.4 (90% CI, 0.1–2.31 × 103) ng/capita for children until age 18, and up to 5.01 × 104 (90% CI, 5.25 × 103–9.33 × 106) particles/capita or 40.7 (90% CI, 0.8–9.85 × 103) ng/capita for adults until age 70 in the body tissue for 1–10 μm particles. Simulated microplastic concentrations in stool agree with empirical data. Chemical absorption from food and ingested microplastic of the nine intake media based on biphasic, reversible, and size-specific sorption kinetics, reveals that the contribution of microplastics to total chemical intake is small. The as-yet-unknown contributions of other food types are discussed in light of future research needs.
中文翻译：
儿童和成人终生累积的微塑性
人类暴露于微塑性是公认的全球性问题，但不确定性，可变性和寿命累积尚未解决。我们提供了针对儿童和成人的概率性终生暴露模型，该模型说明了通过八种食物类型的摄入量以及通过基于生理学的药代动力学子模型的吸入，肠道吸收，胆汁排泄以及与塑料相关的化学暴露。该模型概率地模拟了肠道，身体组织和粪便中的微塑性浓度，后者可以根据经验数据进行验证。使用重新定标方法来确保微塑性丰度数据之间的可比性。儿童和成人的微塑料（1-5000μm）中位数摄入量分别为553微粒/人均/天（184 ng /人/天）和883微粒/人均/天（583 ng /人/天）。人均3（90％CI，7.08×10 2 –1.91×10 6）颗粒或人均6.4（90％CI，0.1–2.31×10 3）ng /人均颗粒，直至5.01×10 4（ 90％CI，5.25×10 3 –9.33×10 6）人均颗粒数或40.7（90％CI，0.8–9.85×10 3）ng /人均成人，直到70岁时身体组织中1–10μm的颗粒。粪便中模拟的微量塑料浓度与经验数据一致。根据双相，可逆和特定大小的吸附动力学，从食物和被摄入的九种摄入介质中的塑料中吸收的化学物质表明，塑料对化学总摄入量的贡献很小。根据未来的研究需求，讨论了其他食物的迄今未知的贡献。
更新日期：2021-04-20
中文翻译：
儿童和成人终生累积的微塑性
人类暴露于微塑性是公认的全球性问题，但不确定性，可变性和寿命累积尚未解决。我们提供了针对儿童和成人的概率性终生暴露模型，该模型说明了通过八种食物类型的摄入量以及通过基于生理学的药代动力学子模型的吸入，肠道吸收，胆汁排泄以及与塑料相关的化学暴露。该模型概率地模拟了肠道，身体组织和粪便中的微塑性浓度，后者可以根据经验数据进行验证。使用重新定标方法来确保微塑性丰度数据之间的可比性。儿童和成人的微塑料（1-5000μm）中位数摄入量分别为553微粒/人均/天（184 ng /人/天）和883微粒/人均/天（583 ng /人/天）。人均3（90％CI，7.08×10 2 –1.91×10 6）颗粒或人均6.4（90％CI，0.1–2.31×10 3）ng /人均颗粒，直至5.01×10 4（ 90％CI，5.25×10 3 –9.33×10 6）人均颗粒数或40.7（90％CI，0.8–9.85×10 3）ng /人均成人，直到70岁时身体组织中1–10μm的颗粒。粪便中模拟的微量塑料浓度与经验数据一致。根据双相，可逆和特定大小的吸附动力学，从食物和被摄入的九种摄入介质中的塑料中吸收的化学物质表明，塑料对化学总摄入量的贡献很小。根据未来的研究需求，讨论了其他食物的迄今未知的贡献。
京公网安备 11010802027423号