We describe the synthesis of eight novel putative mono– and bis–DNA intercalators from a common precursor, 6-bromoindolo[1,2-b][2,7]naphthyridine-5,12-dione. Of these new indoloquinones, our data indicate that two are most likely DNA mono–intercalators, but weaker than ethidium bromide, and two others are DNA bis–intercalators. Our indoloquinones are inactive against mammalian topoisomerase II.

中文翻译：

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6-(Alkylamino)indolo[1,2-b][2,7]naphthyridine-5,12-quinones 的合成和 DNA 结合

我们描述了从常见的前体 6-溴吲哚 [1,2-b][2,7] 萘啶-5,12-二酮合成八种新型推定的单 DNA 和双 DNA 嵌入剂。在这些新的吲哚醌中，我们的数据表明，两种最有可能是 DNA 单嵌入剂，但比溴化乙锭弱，另外两种是 DNA 双嵌入剂。我们的吲哚醌对哺乳动物拓扑异构酶 II 无活性。