A synthetic route towards 1-t-butoxycarbonyl-3-fluoro-3-methylpyrrolidine and 1-t- butoxycarbonyl-3-fluoro-3-methylazetidine, which are interesting building blocks for pharmaceutical compounds, is described. The key steps include a bromofluorination of appropriate alkenyl azides, followed by reduction to the corresponding amines and subsequent cyclization, yielding the 3-fluorinated azaheterocycles.

中文翻译：

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3-氟吡咯烷和3-氟氮杂环丁烷的合成

描述了 1-t-butoxycarbonyl-3-fluoro-3-methylpyrrolidine 和 1-t-butoxycarbonyl-3-fluoro-3-methylazetidine 的合成路线，它们是药物化合物的有趣结构单元。关键步骤包括适当的烯基叠氮化物的溴氟化，然后还原为相应的胺和随后的环化，产生 3-氟化氮杂杂环。