大都会靶向双模态MRI / NIR II成像对头颈部鳞状细胞癌的特异性识别,ACS Biomaterials Science & Engineering

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大都会靶向双模态MRI / NIR II成像对头颈部鳞状细胞癌的特异性识别
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-03-15 , DOI: 10.1021/acsbiomaterials.0c01807
Jun Wu ₁ , Jun Liu ₂ , Bi Lin ₂ , Ruichan Lv ₂ , Ying Yuan ₁ , Xiaofeng Tao ₁

Affiliation

头颈部鳞状细胞癌（HNSCC）是存活率低的最常见的癌症之一，这归因于疾病的早期检测的困难。然而，传统的成像方法在HNSCC的早期诊断中缺乏准确性和敏感性。因此，迫切需要开发一种有效且灵敏的HNSCC成像方法。众所周知，cMet受体在HNSCC肿瘤细胞CAL27和肿瘤组织中过表达。在这里，我们合成了具有cMet靶向结合肽（NaGdF ₄ -PEG-cMBP）的双模式近红外II（NIR II）发光成像和基于T ₁磁共振成像（MRI）的纳米探针。/ NIR II发光和更高的R ₁与市售的compared酸相比，其弛豫度（5.871对3.471 mM ^–1 s ^–1）。此外，掺Yb，Er，Ce的探针的发光成像表明，该材料可以有效地在cMet靶向的HNSCC肿瘤中蓄积。通过双模式T ₁加权MRI和NIR II发光成像方法，可以在皮下和原位HNSCC肿瘤模型中清楚地看到它。结果表明，在不久的将来，我们的cMBP偶联纳米平台可能为HNSCC提供一种新颖且非常有效的非侵入性诊断方法。

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Met-Targeted Dual-Modal MRI/NIR II Imaging for Specific Recognition of Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are one of the most common cancers with poor survival rates, which is attributed to the difficulty in the early detection of disease. However, conventional imaging methods lack accuracy and sensitivity in the early diagnosis of HNSCCs. Thus, there is an urgent need to develop an effective and sensitive approach for HNSCC imaging. As known, the cMet receptor is overexpressed in HNSCC tumor cells CAL27 and tumor tissues. Herein, we synthesize the dual-modal near-infrared II (NIR II) imaging of luminescence and T₁ magnetic resonance imaging (MRI)-based nanoprobes with the cMet targeting binding peptide (NaGdF₄-PEG-cMBP), which has strong upconversion/NIR II luminescence and higher R₁ relaxivity compared with the commercially used gadolinium acid (5.871 vs 3.471 mM^–1 s^–1). Additionally, the luminescence imaging of Yb,Er,Ce-doped probes showed that the material can efficiently accumulate in HNSCC tumors with the cMet-targeted. It can be clearly visualized in both subcutaneous and orthotopic HNSCC tumor models by dual-modal T₁-weighted MRI and NIR II luminescence imaging methods. The results demonstrate that our cMBP-conjugated nanoplatform may provide a novel and very efficient noninvasive diagnostic approach for HNSCC in the near future.

更新日期：2021-04-12

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