Multiplexing NMR experiments by direct detection of multiple free induction decays (FIDs) in a single experiment offers a dramatic increase in the spectral information content and often yields significant improvement in sensitivity per unit time. Experiments with multi-FID detection have been designed with both homonuclear and multinuclear acquisition, and the advent of multiple receivers on commercial spectrometers opens up new possibilities for recording spectra from different nuclear species in parallel. Here we provide an extensive overview of such techniques, designed for applications in liquid- and solid-state NMR as well as in hyperpolarized samples. A brief overview of multinuclear MRI is also provided, to stimulate cross fertilization of ideas between the two areas of research (NMR and MRI). It is shown how such techniques enable the design of experiments that allow structure elucidation of small molecules from a single measurement. Likewise, in biomolecular NMR experiments multi-FID detection allows complete resonance assignment in proteins. Probes with multiple RF microcoils routed to multiple NMR receivers provide an alternative way of increasing the throughput of modern NMR systems, effectively reducing the cost of NMR analysis and increasing the information content at the same time. Solid-state NMR experiments have also benefited immensely from both parallel and sequential multi-FID detection in a variety of multi-dimensional pulse schemes. We are confident that multi-FID detection will become an essential component of future NMR methodologies, effectively increasing the sensitivity and information content of NMR measurements.

通过在单个实验中直接检测多个自由感应衰变 (FID) 的多重 NMR 实验提供了光谱信息内容的显着增加，并且通常会显着提高每单位时间的灵敏度。多 FID 检测实验设计为具有同核和多核采集，商业光谱仪上多个接收器的出现为并行记录不同核物种的光谱开辟了新的可能性。在这里，我们提供了此类技术的广泛概述，这些技术专为液态和固态 NMR 以及超极化样品中的应用而设计。还提供了多核 MRI 的简要概述，以促进两个研究领域（NMR 和 MRI）之间的思想交流。展示了此类技术如何能够设计出允许从单次测量中阐明小分子结构的实验。同样，在生物分子 NMR 实验中，多 FID 检测允许在蛋白质中进行完整的共振分配。将多个射频微线圈路由到多个 NMR 接收器的探头提供了一种增加现代 NMR 系统吞吐量的替代方法，有效降低了 NMR 分析成本，同时增加了信息内容。固态 NMR 实验也从各种多维脉冲方案中的并行和顺序多 FID 检测中受益匪浅。我们相信，多 FID 检测将成为未来 NMR 方法的重要组成部分，有效提高 NMR 测量的灵敏度和信息含量。