In the present work, the ethyl 2-(1 H -benzo[ d ]imidazol-2-yl)acetate ( 3 ) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[ d ]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1 H NMR, 13 C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a , 9b , 9c , 17 , 23b and 38 were of the highest potencies among the synthesized compounds. KEY WORDS : Oxobutanamide, Thiophene, Pyrazole, Pyran, Pyridine Bull. Chem. Soc. Ethiop. 2018 , 32(3), 541-557. DOI: https://dx.doi.org/10.4314/bcse.v32i3.13

中文翻译：

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2-（1H-苯并[D]咪唑-2-基）乙酸乙酯的合成具有抗肿瘤活性的吡唑，噻吩，吡啶和香豆素衍生物

在本工作中，通过与不同化学试剂反应的2-（1 H-苯并[d]咪唑-2-基）乙酸乙酯（3）进行了一系列杂环反应。所得分子为噻吩，吡唑，并入苯并[d]咪唑部分的香豆素衍生物。通过元素分析，1 H NMR，13 C NMR和MS确定所有合成的化合物。新合成产物对三种癌细胞系MCF-7（乳腺癌），NCI-H460（非小细胞肺癌）和SF-268（CNS癌症）的抗肿瘤评价表明，化合物5a，9b，9c ，17、23b和38在合成的化合物中具有最高的效力。关键词：氧代丁酰胺，噻吩，吡唑，吡喃，吡啶牛。化学 Soc。埃塞俄比亚。2018，32（3），541-557。DOI：https：//dx.doi.org/10.4314/bcse.v32i3.13