纳米氢氧化镁对口腔细菌的抗菌活性及其在根管封闭剂中的应用,Medical Science Monitor

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纳米氢氧化镁对口腔细菌的抗菌活性及其在根管封闭剂中的应用
Medical Science Monitor Pub Date : 2020-04-07 , DOI: 10.12659/msm.922920
Yingying Meng ₁ , Dan Zhang ₁ , Xingya Jia ₁ , Keshen Xiao ₂ , Xiao Lin ₃ , Yi Yang ₄ , Dake Xu ₄ , Qiang Wang ₁

Affiliation

背景技术本研究的目的是评估纳米氢氧化镁（NMH）对变形链球菌（S. mutans）的抗菌活性，并探索结合了NMH的AH Plus™封闭剂的抗菌功能。材料/方法通过杀菌试验评估了NMH对变形链球菌的抗菌性能。改良的直接接触测试用于评估与细菌接触5分钟，20分钟和60分钟后未固化的含有NMH的AH Plus的抗菌活性。通过SEM和共聚焦激光扫描显微镜分别研究了固化材料的抗菌作用和表面附着细菌的数量。结果NMH粉末对变形链球菌具有优异的抗菌活性。Mg2 +和OH-不是导致细菌死亡的主要因素。分别孵育5分钟和20分钟后，在AH Plus + 7％NMH组中约有93.1％和98％的变形链球菌被杀死。与单独使用AH Plus相比，含5％或7％NMH的AH Plus对变形链球菌更有效（P <0.05）。而且，AH Plus的抗菌功能在凝固后丧失。NMH使固化的AH Plus在第七天仍然具有抗菌性能。结论NMH可用于AH Plus封闭剂的改良，以消除残留细菌并防止再次感染。NMH使固化的AH Plus在第七天仍然具有抗菌性能。结论NMH可用于AH Plus封闭剂的改良，以消除残留细菌并防止再次感染。NMH使固化的AH Plus在第七天仍然具有抗菌性能。结论NMH可用于AH Plus封闭剂的改良，以消除残留细菌并防止再次感染。

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Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer

Background The goal of the present work was to assess the antibacterial activity of nano-magnesium hydroxide (NMH) against Streptococcus mutans (S. mutans) and to explore the antimicrobial function of AH Plus™ sealer incorporating NMH. Material/Methods The antimicrobial behavior of NMH against S. mutans was evaluated with bactericidal tests. A modified direct contact test was used to assess the antimicrobial activity of unset AH Plus containing NMH after 5 minutes, 20 minutes, and 60 minutes of contact with bacteria. The antimicrobial effects and the amount of surface-adhering bacteria of the solidified materials were explored by SEM and confocal laser scanning microscopy, respectively. Results NMH powder presented excellent antimicrobial activity against S. mutans. Mg2+ and OH− were not the main factors resulting in bacterial death. Approximately 93.1% and 98% of the S. mutans were killed in the AH Plus+7% NMH group after incubation for 5 minutes and 20 minutes, respectively. AH Plus with 5% or 7% NMH were more potent against S. mutans compared with AH Plus alone (P<0.05). Moreover, the antibacterial function of AH Plus was lost after setting. NMH enabled the solidified AH Plus to still have antibacterial properties on the seventh day. Conclusions NMH can be used to modify AH Plus sealer to eradicate residual bacteria and prevent reinfection.

更新日期：2020-04-07

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