The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual‐Functions of Enhanced Osteogenesis and Anti‐Infection,Advanced Healthcare Materials

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The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual‐Functions of Enhanced Osteogenesis and Anti‐Infection
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-03-11 , DOI: 10.1002/adhm.202002020
Mingyu Zhu ₁ , Ju Fang ₁ , Yulei Li ₁ , Chuanxin Zhong ₁ , Shihui Feng ₁ , Xiang Ge ₂ , Haixia Ye ₁ , Xiaofei Wang ₁ , Weiwei Zhu ₁ , Xiong Lu ₃ , Fuzeng Ren ₁

Affiliation

Poor osteogenesis and implant‐associated infection are the two leading causes of failure for dental and orthopedic implants. Surface design with enhanced osteogenesis often fails in antibacterial activity, or vice versa. Herein, a surface design strategy, which overcomes this trade‐off via the synergistic effects of topographical micropatterning and a bilayered nanostructured metallic thin film is presented. A specific microgrooved pattern is fabricated on the titanium surface, followed by sequential deposition of a nanostructured copper (Cu)‐containing tantalum (Ta) (TaCu) layer and a pure Ta cap layer. The microgrooved patterns coupled with the nanorough Ta cap layer shows strong contact guidance to preosteoblasts and significantly enhances the osteogenic differentiation in vitro, while the controlled local sustained release of Cu ions is responsible for high antibacterial activity. Importantly, rat calvarial defect models in vivo further confirm that the synergy of microgrooved patterns and the Ta|TaCu bilayered thin film on titanium surface could effectively promote bone regeneration. The present effective and versatile surface design strategy provides significant insight into intelligent surface engineering that can control biological response at the site of healing in dental and orthopedic implants.

中文翻译：

钛植入物上的地形微图案和Ta | TaCu双层薄膜的协同作用使成骨和抗感染的双重功能得以实现

成骨不良和与种植体相关的感染是导致牙齿和整形外科植入物失败的两个主要原因。具有增强成骨作用的表面设计通常无法发挥抗菌活性，反之亦然。本文提出了一种表面设计策略，该策略通过地形微图案和双层纳米结构金属薄膜的协同效应克服了这一折衷。在钛表面上制作特定的微槽图案，然后依次沉积纳米结构的含铜（Cu）的钽（Ta）（TaCu）层和纯Ta盖层。微槽纹与纳米粗糙的Ta帽层结合在一起，显示出对成骨细胞的强力接触引导，并显着增强了体外成骨细胞的分化，而铜离子的局部持续释放则具有很高的抗菌活性。重要的是，体内大鼠颅骨缺损模型进一步证实了微槽纹图案与钛表面Ta | TaCu双层薄膜的协同作用可以有效地促进骨骼再生。当前有效且通用的表面设计策略为智能表面工程学提供了重要的见识，该技术可以控制牙科和整形外科植入物愈合部位的生物反应。

更新日期：2021-05-05

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