A new and convenient protocol is presented here for the synthesis of 3,6,8-tribromoquinolines via cascade cyclization of N-(3-phenylprop-2-ynyl)anilines employing N-bromosuccinimide as an electrophile. The metal-free process is carried out under mild conditions and is compatible with a variety of substituents. The Sonogashira coupling reaction regioselectively occurs at position C-6 of the obtained products.

中文翻译：

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NBS介导的级联亲电溴化/环化N-（3-苯基丙-2-炔基）苯胺的合成多溴取代的喹啉

本文提出了一种新的方便的方案，用于使用N-溴代琥珀酰亚胺作为亲电试剂，通过N-（3-苯基丙-2-炔基）苯胺的级联环化反应合成3,6,8-三溴喹啉。无金属工艺在温和的条件下进行，并且与多种取代基兼容。Sonogashira偶联反应区域选择性地发生在所得产物的C-6位。