Spatially Organized Functional Bioreactors in Nanoscale Mesoporous MOFs for Cascade Scavenging of Intracellular ROS,Chemistry of Materials

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Spatially Organized Functional Bioreactors in Nanoscale Mesoporous MOFs for Cascade Scavenging of Intracellular ROS
Chemistry of Materials ( IF 7.2 ) Pub Date : 2021-03-12 , DOI: 10.1021/acs.chemmater.1c00123
Ke Li ₁ , Jian Yang ₁ , Jinlou Gu ₁

Affiliation

The creation of artificial microenvironments with specific functionalities to mimic multiple cascade biocatalytic processes in cells is highly desirable. Here, Zr-based large-pore mesoporous metal–organic frameworks (mesoMOFs) were successfully developed for the construction of such spatially organized cascade bioreactors. Thanks to the mediating effect of the Hofmeister ion and the flexibility of Zr-MOFs, large mesopores and functional microporous mesopore walls were integrated into a single nanoplatform, ensuring the efficient mass exchange between the interconnected pore units with different sizes. As a proof of concept, natural superoxide dismutase and catalase mimic were spatially positioned in these hierarchical mesoMOFs, which formed a cascade antioxidant defense system and presented an efficient intracellular reactive oxygen species scavenging ability. This model is expected to set a conceptual guideline for the design of compartmentalized bioreactors in nanoscale MOFs to mediate the complex intracellular catalytic networks.

中文翻译：

纳米级中孔MOFs中的级联清除细胞内ROS的空间组织的功能性生物反应器。

非常需要创建具有特定功能的人造微环境，以模拟细胞中的多个级联生物催化过程。在这里，基于Zr的大孔介孔金属有机骨架（mesoMOF）已成功开发，用于构建这种空间组织的级联生物反应器。得益于Hofmeister离子的介导作用和Zr-MOF的柔性，大的中孔和功能性微孔中孔壁被集成到单个纳米平台中，从而确保了不同大小的相互连接的孔单元之间的有效质量交换。作为概念的证明，天然超氧化物歧化酶和过氧化氢酶模拟物在空间上位于这些分层的mesoMOF中，形成了一个级联的抗氧化防御系统，并表现出有效的细胞内活性氧清除能力。预期该模型将为纳米MOF中的间隔化生物反应器设计提供概念指导，以介导复杂的细胞内催化网络。

更新日期：2021-03-23

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