Sulfobetaine Methacrylate Polymers of Unconventional Polyzwitterion Architecture and Their Antifouling Properties,Biomacromolecules

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Sulfobetaine Methacrylate Polymers of Unconventional Polyzwitterion Architecture and Their Antifouling Properties
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-03-12 , DOI: 10.1021/acs.biomac.0c01705
Eric Schönemann ₁ , Julian Koc ₂ , Jana F Karthäuser ₂ , Onur Özcan ₂ , Dirk Schanzenbach ₁ , Lisa Schardt ₂ , Axel Rosenhahn ₂ , André Laschewsky _{1,

3}

Affiliation

Combining high hydrophilicity with charge neutrality, polyzwitterions are intensely explored for their high biocompatibility and low-fouling properties. Recent reports indicated that in addition to charge neutrality, the zwitterion’s segmental dipole orientation is an important factor for interacting with the environment. Accordingly, a series of polysulfobetaines with a novel architecture was designed, in which the cationic and anionic groups of the zwitterionic moiety are placed at equal distances from the backbone. They were investigated by in vitro biofouling assays, covering proteins of different charges and model marine organisms. All polyzwitterion coatings reduced the fouling effectively compared to model polymer surfaces of poly(butyl methacrylate), with a nearly equally good performance as the reference polybetaine poly(3-(N-(2-(methacryloyloxy)ethyl)-N,N-dimethylammonio)propanesulfonate). The specific fouling resistance depended on the detailed chemical structure of the polyzwitterions. Still, while clearly affecting the performance, the precise dipole orientation of the sulfobetaine group in the polyzwitterions seems overall to be only of secondary importance for their antifouling behavior.

中文翻译：

非常规两性离子结构的磺基甜菜碱甲基丙烯酸酯聚合物及其防污性能

结合了高亲水性和电荷中性，人们对聚两性离子的高生物相容性和低结垢特性进行了深入研究。最近的报道表明，除电荷中性外，两性离子的分段偶极子取向是与环境相互作用的重要因素。因此，设计了一系列具有新颖结构的聚磺基甜菜碱，其中两性离子部分的阳离子和阴离子基团与主链的距离相等。通过体外生物污损分析法对它们进行了研究，涵盖了不同电荷的蛋白质并模拟了海洋生物。与聚甲基丙烯酸丁酯的模型聚合物表面相比，所有聚两性离子涂料均有效地减少了结垢，其性能几乎与参考聚甜菜碱聚（3-（N-（2-（甲基丙烯酰氧基）乙基）-N，N-二甲基铵）丙烷磺酸盐）。具体的防污性取决于聚两性离子的详细化学结构。尽管如此，尽管明显影响性能，但是聚两性离子中磺基甜菜碱基团的精确偶极取向似乎总体上对于它们的防污行为仅是次要的。

更新日期：2021-04-12

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