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Synthetic Applications of Proton-Coupled Electron Transfer
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2016-07-29 00:00:00 , DOI: 10.1021/acs.accounts.6b00272 Emily C. Gentry 1 , Robert R. Knowles 1
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2016-07-29 00:00:00 , DOI: 10.1021/acs.accounts.6b00272 Emily C. Gentry 1 , Robert R. Knowles 1
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Redox events in which an electron and proton are exchanged in a concerted elementary step are commonly referred to as proton-coupled electron transfers (PCETs). PCETs are known to operate in numerous important biological redox processes, as well as recent inorganic technologies for small molecule activation. These studies suggest that PCET catalysis might also function as a general mode of substrate activation in organic synthesis. Over the past three years, our group has worked to advance this hypothesis and to demonstrate the synthetic utility of PCET through the development of novel catalytic radical chemistries. The central aim of these efforts has been to demonstrate the ability of PCET to homolytically activate a wide variety of common organic functional groups that are energetically inaccessible using known molecular H atom transfer catalysts.
中文翻译：
质子耦合电子转移的合成应用
在一致的基本步骤中交换电子和质子的氧化还原事件通常称为质子耦合电子转移（PCET）。众所周知，PCET可以在许多重要的生物氧化还原过程中运行，以及用于小分子活化的最新无机技术。这些研究表明，PCET催化作用还可以作为有机合成中底物活化的一般模式。在过去的三年中，我们的小组致力于发展这一假设，并通过开发新型催化自由基化学物质来证明PCET的合成效用。
更新日期：2016-07-29
中文翻译：
质子耦合电子转移的合成应用
在一致的基本步骤中交换电子和质子的氧化还原事件通常称为质子耦合电子转移（PCET）。众所周知，PCET可以在许多重要的生物氧化还原过程中运行，以及用于小分子活化的最新无机技术。这些研究表明，PCET催化作用还可以作为有机合成中底物活化的一般模式。在过去的三年中，我们的小组致力于发展这一假设，并通过开发新型催化自由基化学物质来证明PCET的合成效用。
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