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Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Alcoholism: Clinical & Experimental Research Pub Date : 2020-09-20 , DOI: 10.1111/acer.14441
Chloe N. Shields 1 , Christina M. Gremel 1, 2
Alcoholism: Clinical & Experimental Research Pub Date : 2020-09-20 , DOI: 10.1111/acer.14441
Chloe N. Shields 1 , Christina M. Gremel 1, 2
Affiliation
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Alcoholism is a persistent worldwide problem associated with long-lasting impairments to decision-making processes. Some aspects of dysfunction are thought to reflect alcohol-induced changes to relevant brain areas such as the orbitofrontal cortex (OFC). In this review, we will examine how chronic alcohol exposure alters OFC function to potentially contribute to maladaptive decision-making, and explore experimental behavioral approaches that may be better suited to test whether alcohol dependence disrupts OFC's function. We argue that although past works suggest impairments in aspects of OFC function, more information may be gained by specifically targeting tasks to the broader function of OFC as put forth by the recent hypothesis of OFC as a "cognitive map" of task space. Overall, we suggest that such a focus could provide a better understanding of how OFC function changes in alcohol dependence, and could inform better assessment tools and treatment options for clinicians working with this population.
中文翻译:
酒精依赖性眼眶额叶皮层的综述:破坏性的认知图吗?
酒精中毒是一个长期存在的全球性问题,与决策流程的长期损害相关。功能障碍的某些方面被认为反映了酒精引起的相关大脑区域(如眶额皮质(OFC))的变化。在这篇综述中,我们将研究长期饮酒如何改变OFC功能以潜在地导致适应不良的决策,并探索可能更适合测试酒精依赖是否破坏OFC功能的实验行为方法。我们认为,尽管过去的工作表明OFC功能的某些方面存在缺陷,但可以通过将任务专门针对OFC的更广泛功能来获得更多信息,这是由OFC的最新假设作为任务空间的“认知图”提出的。全面的,
更新日期:2020-09-20
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
酒精依赖性眼眶额叶皮层的综述:破坏性的认知图吗?
酒精中毒是一个长期存在的全球性问题,与决策流程的长期损害相关。功能障碍的某些方面被认为反映了酒精引起的相关大脑区域(如眶额皮质(OFC))的变化。在这篇综述中,我们将研究长期饮酒如何改变OFC功能以潜在地导致适应不良的决策,并探索可能更适合测试酒精依赖是否破坏OFC功能的实验行为方法。我们认为,尽管过去的工作表明OFC功能的某些方面存在缺陷,但可以通过将任务专门针对OFC的更广泛功能来获得更多信息,这是由OFC的最新假设作为任务空间的“认知图”提出的。全面的,