Metal-phenolic networks for cancer theranostics,Biomaterials Science

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Metal-phenolic networks for cancer theranostics
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-3-1 , DOI: 10.1039/d0bm02064h
Peng Liu _{1,

2,

3,

4} , Xinyi Shi _{1,

2,

3,

4} , Shenghui Zhong _{1,

2,

3,

4,

5} , Ying Peng _{1,

2,

3,

4} , Yan Qi _{4,

6,

7,

8} , Jinsong Ding _{1,

2,

3,

4} , Wenhu Zhou _{1,

2,

3,

4}

Affiliation

Metal-phenolic networks (MPNs) have shown promising potential in biomedical applications since they provide a rapid, simple and robust way to construct multifunctional nanoplatforms. As a novel nanomaterial self-assembled from metal ions and polyphenols, MPNs can be prepared to assist the theranostics of cancer owing to their bio-adhesiveness, good biocompatibility, versatile drug loading, and stimuli-responsive profile. This Critical Review aims to summarize recent progress in MPN-based nanoplatforms for multimodal tumor therapy and imaging. First, the advantages of MPNs as drug carriers are summarized. Then, various tumor therapeutic modalities based on MPNs are introduced. Next, MPN-based theranostic systems are reviewed. In terms of in vivo applications, specific attention is paid to their biosafety, biodistribution, as well as excretion. Finally, some problems and limitations of MPNs are discussed, along with a future perspective on the field.

中文翻译：

用于癌症治疗的金属酚醛网络

金属酚醛网络（MPN）在生物医学应用中已显示出令人鼓舞的潜力，因为它们提供了构建多功能纳米平台的快速，简单和强大的方法。作为一种由金属离子和多酚自组装的新型纳米材料，MPN由于其生物粘附性，良好的生物相容性，通用的药物载量和刺激反应特性，因此可以制备来协助癌症的治疗学。这篇重要评论旨在总结用于多峰肿瘤治疗和成像的基于MPN的纳米平台的最新进展。首先，总结了MPN作为药物载体的优势。然后，介绍了基于MPN的各种肿瘤治疗方法。接下来，回顾了基于MPN的诊断系统。就体内而言应用中，应特别注意其生物安全性，生物分布和排泄。最后，讨论了MPN的一些问题和局限性，以及该领域的未来前景。

更新日期：2021-03-10

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