Background Prognosis in cardiac arrest (CA) patients has been challenging. We sought to investigate prognostic value combining serial disseminated intravascular coagulation (DIC) score and neuron-specific enolase (NSE) in out-of-hospital cardiac arrest (OHCA) patients. Methods Sixty-one consecutive patients successfully resuscitated after CA were included in the analysis. DIC score and NSE levels were serially analyzed after return of spontaneous circulation (ROSC). The outcome measure was death before hospital discharge. Prognostication performance was assessed as the area under the receiver-operating characteristics curve (AUC). Hosmer-Lemeshow test was used for internal validation of predictive models. Calibration curves were drawn to visualize the results of tests. Results The NSE levels continued to increase in the first 72 h in non-survivors. In survivors, the NSE levels decreased after 48 h. Both DIC score at 48 h and NSE level at 48 h were good predictors of outcome. The AUC for predictive mortality in OHCA patients was 0.869 (95% CI, 0.781-0.956) for DIC score at 48 h combining NSE at 24 h, 0.878 (95% CI, 0.791-0.965) for DIC score at 48 h combining NSE at 48 h and 0.882 (95% CI, 0.792-0.972) for DIC score at 48 h combining NSE at 72 h, respectively. Significance of Hosmer-Lemeshow test was 0.488, 0.324, 0.011 for each combination. Conclusions Serial DIC score combined with measurement of NSE levels is a useful and accessible tool for prognostication following OHCA.

中文翻译：

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连续弥散性血管内凝血评分与神经元特异性烯醇化酶可预测心脏骤停的死亡率-一项初步研究

背景心脏骤停（CA）患者的预后一直充满挑战。我们试图调查结合散布的血管内凝血（DIC）评分和神经元特异性烯醇化酶（NSE）在院外心脏骤停（OHCA）患者中的预后价值。方法对连续性CA成功复苏的61例患者进行分析。自发循环（ROSC）恢复后，连续分析DIC评分和NSE水平。结果指标是出院前的死亡。将预后表现评估为接受者工作特征曲线（AUC）下的面积。Hosmer-Lemeshow检验用于预测模型的内部验证。绘制校准曲线以可视化测试结果。结果非幸存者在头72小时内NSE水平持续升高。在幸存者中，NSE水平在48小时后下降。48小时的DIC评分和48小时的NSE水平都是预后的良好预测指标。OHCA患者的预测死亡的AUC在48小时时合并DSE时在48 h时DIC评分为0.869（95％CI，0.781-0.956），在48小时时合并NSE时DIC评分为0.878（95％CI，0.791-0.965）。 48小时的DIC评分分别为48小时和0.882（95％CI，0.792-0.972），结合72小时的NSE。每种组合的Hosmer-Lemeshow检验的显着性分别为0.488、0.324、0.011。结论连续DIC评分结合NSE水平测量是OHCA预后的有用且可访问的工具。956）48小时的DIC得分与24小时的NSE结合，48小时的DIC得分为0.878（95％CI，0.791-0.965），48小时的DIC得分为0.882（95％CI，0.792-0.972） 48小时分别在72小时结合NSE。每种组合的Hosmer-Lemeshow检验的显着性分别为0.488、0.324、0.011。结论连续DIC评分结合NSE水平测量是OHCA预后的有用且可访问的工具。956）在48小时时结合DSE的DIC得分在24小时时结合DSE得分，在48小时时结合DSE的0.878（95％CI，0.791-0.965），而在48小时时结合DSE结合在0.8h（95％CI，0.792-0.972） 48小时分别在72小时结合NSE。每种组合的Hosmer-Lemeshow检验的显着性分别为0.488、0.324、0.011。结论连续DIC评分结合NSE水平测量是OHCA预后的有用且可访问的工具。