当前位置：
X-MOL 学术
›
Org. Process Res. Dev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Development of a One-Step Synthesis of 5-Amino-1H-imidazole-4-carboxamide
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2021-03-09 , DOI: 10.1021/acs.oprd.1c00013 Ji Qi 1 , Jingjun Yin 2 , Donghong Li 3 , Song Chen 3 , Zhenguo Liu 3
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2021-03-09 , DOI: 10.1021/acs.oprd.1c00013 Ji Qi 1 , Jingjun Yin 2 , Donghong Li 3 , Song Chen 3 , Zhenguo Liu 3
Affiliation
|
An innovative and efficient synthesis of 5-amino-1H-imidazole-4-carboxamide (AIC) from commercially available hypoxanthine (∼$30/kg) is described. The development of the key hydrolysis step and a practical isolation enables a highly efficient one-step manufacturing process for AIC with minimal environmental impact and significant reduction of production cost.
中文翻译：
一步合成5-氨基-1 H-咪唑-4-羧酰胺的进展
描述了一种从市售的次黄嘌呤（约30美元/千克）合成5-氨基-1 H-咪唑-4-羧酰胺（AIC）的有效方法。关键水解步骤的开发和实际隔离使AIC的高效一步制造过程成为可能，对环境的影响最小，并且生产成本显着降低。
更新日期：2021-03-19
中文翻译：
一步合成5-氨基-1 H-咪唑-4-羧酰胺的进展
描述了一种从市售的次黄嘌呤（约30美元/千克）合成5-氨基-1 H-咪唑-4-羧酰胺（AIC）的有效方法。关键水解步骤的开发和实际隔离使AIC的高效一步制造过程成为可能，对环境的影响最小，并且生产成本显着降低。
京公网安备 11010802027423号