An innovative and efficient synthesis of 5-amino-1H-imidazole-4-carboxamide (AIC) from commercially available hypoxanthine (∼$30/kg) is described. The development of the key hydrolysis step and a practical isolation enables a highly efficient one-step manufacturing process for AIC with minimal environmental impact and significant reduction of production cost.

中文翻译：

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一步合成5-氨基-1 H-咪唑-4-羧酰胺的进展

描述了一种从市售的次黄嘌呤（约30美元/千克）合成5-氨基-1 H-咪唑-4-羧酰胺（AIC）的有效方法。关键水解步骤的开发和实际隔离使AIC的高效一步制造过程成为可能，对环境的影响最小，并且生产成本显着降低。