Chirality-Directed Regioselectivity: An Approach for the Synthesis of Alternating Poly(Lactic-co-Glycolic Acid),Journal of the American Chemical Society

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Chirality-Directed Regioselectivity: An Approach for the Synthesis of Alternating Poly(Lactic-co-Glycolic Acid)
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-03-09 , DOI: 10.1021/jacs.1c00248
Yiye Lu ₁ , Jordan H Swisher ₂ , Tara Y Meyer ₂ , Geoffrey W Coates ₁

Affiliation

We report the synthesis of alternating poly(lactic-co-glycolic acid) via a regioselective ring-opening polymerization of (S)-methyl glycolide. An enantiopure aluminum salen catalyst with binaphthyl backbone facilitates the regioselective ring-opening of this unsymmetrical cyclic diester exclusively at the glycolide acyl–oxygen bond site. This living, chain-growth polymerization is able to reach low dispersities with tailored molecular weights. Quantitative regioselectivity calculations and sequence error analysis have been established for this sequence-controlled polymer.

中文翻译：

手性定向区域选择性：一种合成交替聚（乳酸-共-乙醇酸）的方法

我们报告了通过（S）-甲基乙交酯的区域选择性开环聚合合成交替聚（乳酸-共-乙醇酸）。具有联萘骨架的对映纯铝沙伦催化剂促进了这种不对称环二酯的区域选择性开环，仅在乙交酯酰基 - 氧键位点。这种活性的链增长聚合能够以定制的分子量达到低分散度。已经为这种序列控制的聚合物建立了定量区域选择性计算和序列错误分析。

更新日期：2021-03-24

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