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Effective Antibacterial Activity of Degradable Copper-Doped Phosphate-Based Glass Nanozymes
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-03-08 , DOI: 10.1021/acsami.0c22746
Yifan Liu 1 , Ning Nie 1 , Huanfeng Tang 1 , Congrou Zhang 2 , Kezheng Chen 1 , Wei Wang 1 , Jianfeng Liu 1, 2
Affiliation  

Copper-containing antimicrobials are highly valuable in the field of medical disinfectants owing to their well-known high antimicrobial efficacy. Artificially synthesized nanozymes which can increase the level of reactive oxygen species (ROS) in the bacterial system have become research hotspots. Herein, we describe the design and fabrication of degradable Cu-doped phosphate-based glass (Cu-PBG) nanozyme, which can achieve excellent antibacterial effects against Gram-positive and Gram-negative bacteria. The antibacterial mechanism is based on the generation of ROS storm and the release of copper. It behaves like a peroxidase in wounds which are acidic and exerts lethal oxidative stress on bacteria via catalyzing the decomposition of H2O2 into hydroxyl radicals (OH). Quite different from any other reported nanozymes, the Cu-PBG is intrinsically degradable due to its phosphate glass nature. It gradually degrades and releases copper ions in a physiological environment, which further enhances the inhibition efficiency. Satisfactory antibacterial effects are verified both in vitro and in vivo. Being biodegradable, the prepared Cu-PBG exhibits excellent in vivo biocompatibility and does not cause any adverse effects caused by its long-time residence time in living organisms. Collectively, these results indicate that the Cu-PBG nanozyme could be used as an efficient copper-containing antimicrobial with great potential for clinical translation.

中文翻译:

可降解的铜掺杂磷酸盐基玻璃纳米酶的有效抗菌活性

含铜抗菌剂由于其众所周知的高抗菌功效而在医疗消毒剂领域具有很高的价值。可以增加细菌系统中活性氧(ROS)水平的人工合成纳米酶已成为研究热点。在本文中,我们描述了可降解的铜掺杂磷酸盐基玻璃(Cu-PBG)纳米酶的设计和制造,该酶对革兰氏阳性和革兰氏阴性细菌具有出色的抗菌作用。抗菌机制基于ROS风暴的产生和铜的释放。它在酸性伤口中的表现类似于过氧化物酶,并通过催化H 2 O 2的分解对细菌产生致命的氧化应激。变成羟基( OH)。与任何其他已报道的纳米酶完全不同的是,由于其磷酸盐玻璃的性质,Cu-PBG本质上是可降解的。它在生理环境中逐渐降解并释放出铜离子,从而进一步提高了抑制效率。体外体内均证实了令人满意的抗菌效果。所制备的Cu-PBG具有可生物降解性,在体内具有出色生物相容性,不会因其在生物体内的长期停留时间而引起任何不利影响。总体而言,这些结果表明,Cu-PBG纳米酶可以用作有效的含铜抗菌剂,具有很大的临床翻译潜力。
更新日期:2021-03-17
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