The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe3O4@C18 core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections.

中文翻译：

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抗生物膜Fe3O4 @ C18- [1,3,4]噻二唑[3,2-a]嘧啶-4-鎓-2-硫醇盐衍生物核-壳纳米涂层

5,7-二甲基[1,3,4]噻二唑[3,2-a]嘧啶-4-氧-2-硫盐（1）和7-甲基-5-苯基[1,3,4]噻二唑通过单晶X射线衍射充分表征了[3，2-a]嘧啶-4-硫-2-硫酸盐（2）。它们的超分子结构是通过两种化合物的π–π堆积和C = S–π相互作用建立的。将测试化合物嵌入到Fe3O4 @ C18核壳纳米涂层中可以提高对导管表面上白色念珠菌生物膜的保护程度，这表明这些生物活性纳米涂层可以进一步发展为对抗生物膜相关真菌感染的非细胞毒性策略。