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Plasmonic-Fluorescent Janus Ag/Ag2S Nanoparticles for In Situ H2O2-Activated NIR-II Fluorescence Imaging
Nano Letters ( IF 9.6 ) Pub Date : 2021-03-08 , DOI: 10.1021/acs.nanolett.1c00197 Xuan Zhang 1 , Wenli Wang 1 , Lichao Su 1 , Xiaoguang Ge 1 , Jiamin Ye 1 , Caiyan Zhao 1 , Yu He 1 , Huanghao Yang 1 , Jibin Song 1 , Hongwei Duan 2
Nano Letters ( IF 9.6 ) Pub Date : 2021-03-08 , DOI: 10.1021/acs.nanolett.1c00197 Xuan Zhang 1 , Wenli Wang 1 , Lichao Su 1 , Xiaoguang Ge 1 , Jiamin Ye 1 , Caiyan Zhao 1 , Yu He 1 , Huanghao Yang 1 , Jibin Song 1 , Hongwei Duan 2
Affiliation
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Silver sulfide (Ag2S) has gained widespread attention in second near-infrared (950–1700 nm, NIR-II) window imaging because of its high fluorescence quantum yield and low toxicity. However, its “always on” fluorescence shows inapplicability for targeted molecule-activated biomedical applications. Herein, we first developed a novel silver/silver sulfide Janus nanoparticle (Ag/Ag2S JNP) for specific activatable fluorescence imaging in the NIR-II window. Inner-particle electron compensation from Ag to Ag2S upon laser irradiation endowed JNPs an “off” state of fluorescence, whereas the oxidization of Ag incubated with H2O2, decreasing the electron-transfer effect and illuminating the NIR-II fluorescence of the Ag2S part. In contrast, the absorption of Ag/Ag2S JNPs slightly decreased in an H2O2-dependent manner, showing an activated photoacoustic imaging mechanism. The Ag/Ag2S JNPs were used for noninvasive location and diagnosis of diseases in vivo, such as for liver injury and cancer, with high sensitivity and accuracy.
中文翻译：
等离子荧光Janus Ag / Ag 2 S纳米粒子用于原位H 2 O 2活化的NIR-II荧光成像
硫化银（Ag 2 S）因其高荧光量子产率和低毒性而在第二次近红外（950-1700 nm，NIR-II）窗口成像中得到了广泛的关注。但是，其“始终亮着”的荧光显示不适用于靶向分子激活的生物医学应用。在这里，我们首先开发了一种新型的银/硫化银Janus纳米粒子（Ag / Ag 2 S JNP），用于在NIR-II窗口中进行特定的可激活荧光成像。激光辐照后，从Ag到Ag 2 S的颗粒内电子补偿使JNPs处于荧光的“关闭”状态，而与H 2 O 2孵育的Ag的氧化，降低了电子转移效应并照亮了NIR-II荧光。银2 S部分。相比之下，Ag / Ag 2 S JNP的吸收以H 2 O 2依赖性的方式稍微降低，显示出激活的光声成像机制。Ag / Ag 2 S JNPs具有很高的灵敏度和准确性，可用于无创性定位和体内疾病诊断，例如肝损伤和癌症。
更新日期：2021-03-24
中文翻译：
等离子荧光Janus Ag / Ag 2 S纳米粒子用于原位H 2 O 2活化的NIR-II荧光成像
硫化银（Ag 2 S）因其高荧光量子产率和低毒性而在第二次近红外（950-1700 nm，NIR-II）窗口成像中得到了广泛的关注。但是，其“始终亮着”的荧光显示不适用于靶向分子激活的生物医学应用。在这里，我们首先开发了一种新型的银/硫化银Janus纳米粒子（Ag / Ag 2 S JNP），用于在NIR-II窗口中进行特定的可激活荧光成像。激光辐照后，从Ag到Ag 2 S的颗粒内电子补偿使JNPs处于荧光的“关闭”状态，而与H 2 O 2孵育的Ag的氧化，降低了电子转移效应并照亮了NIR-II荧光。银2 S部分。相比之下，Ag / Ag 2 S JNP的吸收以H 2 O 2依赖性的方式稍微降低，显示出激活的光声成像机制。Ag / Ag 2 S JNPs具有很高的灵敏度和准确性，可用于无创性定位和体内疾病诊断，例如肝损伤和癌症。
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