Abstract

Novel rel-(5R,5aR,11bS)-5-methyl-2,6-dioxo-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4΄,3΄:4,5]thiopyrano[2,3-d][1,3]thiazole-5-carboxylic acids were synthesized in 63–72% yields via tandem acylation-hetero-Diels–Alder reaction of 5-(2-hydroxybenzylidene)-4-thioxo-2-thiazolidinones with citraconic acid and its anhydride. The regio- and stereochemistry of the process was confirmed by NMR spectral data and a single-crystal X-ray diffraction analysis.

中文翻译：

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新硫代吡喃并[2,3-d] [1,3]噻唑衍生物的合成中柠檬酸及其酸酐基杂Diels-Alder反应

摘要

新型rel-（5 R，5a R，11b S）-5-甲基-2,6-二氧代-3,5a，6,11b-四氢-2H，5H -chromeno [4΄，3΄：4,5]硫代吡喃并[2,3- d ] [1,3]噻唑-5-羧酸通过串联酰化反应合成，产率为63-72％-杂-Diels-5-（2-羟基苄叉）-4-硫代氧杂-Alder反应2-噻唑烷酮与柠康酸及其酸酐。通过NMR光谱数据和单晶X射线衍射分析证实了该方法的区域和立体化学。