In the large family of heterocyclic chemistry, coumarin and its derivatives have significant role due to their distinct applications, abundant availability in nature and various routes for its synthesis. The main aim of this research is to synthesize 4-(4-amino phenyl)morpholine-3-one substituted coumarin derivatives. Some researchers [1,2] reported several natural and synthetic coumarin derivatives which behaves as antimicrobial agents. Novobiocin and chlorobiocin are important class of antimicrobials compounds containing coumarin ring [3]. Some substituted coumarin derivatives have antibacterial potential and DNA Gyrase inhibitor potential [4]. Di Braccio et al. [5] synthesized coumarin based hydrazine derivative which have antimicrobial property. In the present work, we report the synthesis of 4-(4-((3-nitro-2-oxo-2H-chromen-4-yl)amino)phenyl)morpholine-3-one by a novel synthetic route by chloroamine coupling. The interesting chemical and physical properties and the pharmacological effects of aminocoumarin derivatives were the main motivation for starting this research [6]. At first, the 4-amino compound was synthesized as a starting compound for the synthesis of large spectra of new coumarin derivatives [7]. Synthesis of Substituted 4-(4-((3-Nitro-2-oxo-2H-chromene-4yl)amino)phenyl)morpholine-3-one Coumarin Derivatives

中文翻译：

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取代的 4-(4-((3-Nitro-2-oxo-2H-chromene-4-yl)amino)phenyl)morpholine-3-one Coumarin 衍生物的合成

在杂环化学的大家族中，香豆素及其衍生物由于其独特的应用、在自然界中的丰富可得性以及其合成途径多样而具有重要作用。本研究的主要目的是合成 4-(4-amino phenyl)morpholine-3-one 取代香豆素衍生物。一些研究人员 [1,2] 报道了几种天然和合成的香豆素衍生物，它们具有抗菌作用。新生霉素和氯生菌素是一类重要的含有香豆素环的抗菌化合物[3]。一些取代的香豆素衍生物具有抗菌潜力和 DNA 旋转酶抑制剂潜力 [4]。迪布拉乔等人。[5] 合成了具有抗菌性能的香豆素基肼衍生物。在目前的工作中，我们报告了 4-(4-((3-nitro-2-oxo-2H-chromen-4-yl)amino)phenyl)morpholine-3-one 通过氯胺偶联的新合成路线的合成。氨基香豆素衍生物有趣的化学和物理特性以及药理作用是开始这项研究的主要动机 [6]。最初，合成了 4-氨基化合物作为合成大光谱新香豆素衍生物的起始化合物 [7]。取代的 4-(4-((3-Nitro-2-oxo-2H-chromene-4yl)amino)phenyl)morpholine-3-one Coumarin 衍生物的合成 合成了 4-氨基化合物作为合成大光谱新香豆素衍生物的起始化合物 [7]。取代的 4-(4-((3-Nitro-2-oxo-2H-chromene-4yl)amino)phenyl)morpholine-3-one Coumarin 衍生物的合成 合成了 4-氨基化合物作为合成大光谱新香豆素衍生物的起始化合物 [7]。取代的 4-(4-((3-Nitro-2-oxo-2H-chromene-4yl)amino)phenyl)morpholine-3-one Coumarin 衍生物的合成