The aim of this study was to synthesis and evaluation of the topical anti-inflammatory activity of Dimethyl 4oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate. It was prepared by aldol condensation of benzaldehyde and acetone followed by Michael addition of dimethyl malonate. The optimum concentration of the compound was determined by comparing the anti-inflammatory effect of ointment preparations at different concentrations. The anti-inflammatory effects were studied by using carrageenan-induced paw edema method in rat and xylene induced rat ear edema. Good effect was observed with ointment containing 4% and 5% of the compound II concentration. The results showed that the drug had an obvious anti-inflammatory effect as an external preparation and the activity is comparable to that of the standard ointment.

中文翻译：

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4-Oxo-2,6-二苯基环己烷-1,1-二甲酸二甲酯局部抗炎活性的合成、表征和评价

本研究的目的是合成和评价 4oxo-2,6-二苯基环己烷-1,1-二甲酸二甲酯的局部抗炎活性。它是通过苯甲醛和丙酮的羟醛缩合然后迈克尔加成丙二酸二甲酯制备的。通过比较不同浓度软膏制剂的抗炎作用，确定化合物的最佳浓度。通过使用角叉菜胶诱导的大鼠足部水肿法和二甲苯诱导的大鼠耳部水肿法研究抗炎作用。使用含有 4% 和 5% 化合物 II 浓度的软膏观察到良好的效果。结果表明，该药物作为外用制剂具有明显的抗炎作用，其活性与标准软膏相当。