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1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole
Molbank Pub Date : 2018-10-04 , DOI: 10.3390/m1023
Jean Guillon , Solène Savrimoutou , Sandra Rubio , Vanessa Desplat

The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines).

中文翻译:

1-甲基-3- {4-[(4-(2-氧代-2,3-二氢-1H-苯并咪唑-1-基)哌啶-1-基)苄基]}-2-苯基吲哚

1-甲基-3- {4-[(4-(2-氧代-2,3-二氢-1H-苯并咪唑-1-基)哌啶-1-基)苄基]}-2-苯基吲哚化合物已成功制备通过多步途径从2-苯基吲哚开始合成。通过FTIR,1H-NMR,13C-NMR和HRMS光谱分析对这种新的吲哚衍生物进行结构表征。标题化合物显示出对五种白血病细胞系(K562,HL60,U937,U266和Jurkat细胞系)的高细胞毒性潜能。
更新日期:2018-10-04
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