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Fabrication of PEGylated porphyrin/reduced graphene oxide/doxorubicin nanoplatform for tumour combination therapy
Polymer International ( IF 2.9 ) Pub Date : 2021-03-02 , DOI: 10.1002/pi.6216 Weiqian Ma 1 , Huailin Yang 1 , Yanfang Hu 2 , Li Chen 1
Polymer International ( IF 2.9 ) Pub Date : 2021-03-02 , DOI: 10.1002/pi.6216 Weiqian Ma 1 , Huailin Yang 1 , Yanfang Hu 2 , Li Chen 1
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In cancer treatment, combination therapy has been considered as an attractive strategy to lower side effects and enhance therapeutic efficacy. Herein, we fabricated a kind of reduced-graphene-oxide-based drug delivery system for combination therapy, in which reduced graphene oxide (rGO) as photothermal agent and drug carrier was modified by PEGylated (PEG, polyethylene glycol) tetrahydroxyphenyl porphyrin (THPPEG) via a π–π stacking interaction. The obtained rGO/THPPEG not only showed good biocompatibility and water solubility, but also realized the combination of photothermal therapy with photodynamic therapy. The rGO/THPPEG nanoparticles with stable nanosize were demonstrated by Fourier transform infrared spectroscopy, Raman spectroscopy, TGA, X-ray photoelectron spectroscopy, TEM images and dynamic light scattering. To verify the feasibility of delivering drugs, doxorubicin (DOX) was chosen to prepare rGO/THPPEG/DOX, realizing synergetic photothermal/photodynamic/chemotherapy. The data of in vitro experiments indicated that rGO/THPPEG/DOX could obviously inhibit tumour growth, outlining the significant potential for future cancer treatment. © 2021 Society of Industrial Chemistry.
中文翻译：
用于肿瘤联合治疗的聚乙二醇化卟啉/还原氧化石墨烯/阿霉素纳米平台的制备
在癌症治疗中，联合治疗被认为是降低副作用和提高治疗效果的有吸引力的策略。在此，我们制造了一种用于联合治疗的基于还原氧化石墨烯的药物递送系统，其中还原氧化石墨烯（rGO）作为光热剂和药物载体被聚乙二醇化（PEG，聚乙二醇）四羟基苯基卟啉（THPPEG）修饰。通过 π-π 堆积相互作用。得到的rGO/THPPEG不仅表现出良好的生物相容性和水溶性，而且实现了光热疗法与光动力疗法的结合。通过傅里叶变换红外光谱、拉曼光谱、TGA、X 射线光电子能谱、TEM 图像和动态光散射证明了具有稳定纳米尺寸的 rGO/THPPEG 纳米粒子。为了验证递送药物的可行性，选择阿霉素（DOX）制备rGO/THPPEG/DOX，实现协同光热/光动力/化疗。的数据体外实验表明，rGO/THPPEG/DOX 可以明显抑制肿瘤生长，勾勒出未来癌症治疗的巨大潜力。© 2021 工业化学学会。
更新日期：2021-03-02
中文翻译：
用于肿瘤联合治疗的聚乙二醇化卟啉/还原氧化石墨烯/阿霉素纳米平台的制备
在癌症治疗中，联合治疗被认为是降低副作用和提高治疗效果的有吸引力的策略。在此，我们制造了一种用于联合治疗的基于还原氧化石墨烯的药物递送系统，其中还原氧化石墨烯（rGO）作为光热剂和药物载体被聚乙二醇化（PEG，聚乙二醇）四羟基苯基卟啉（THPPEG）修饰。通过 π-π 堆积相互作用。得到的rGO/THPPEG不仅表现出良好的生物相容性和水溶性，而且实现了光热疗法与光动力疗法的结合。通过傅里叶变换红外光谱、拉曼光谱、TGA、X 射线光电子能谱、TEM 图像和动态光散射证明了具有稳定纳米尺寸的 rGO/THPPEG 纳米粒子。为了验证递送药物的可行性，选择阿霉素（DOX）制备rGO/THPPEG/DOX，实现协同光热/光动力/化疗。的数据体外实验表明，rGO/THPPEG/DOX 可以明显抑制肿瘤生长，勾勒出未来癌症治疗的巨大潜力。© 2021 工业化学学会。
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