A method for the synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazole derivatives by the Lewis acid- and base-co-mediated reaction of perfluoroacetyl diazoester with ketones is reported. A series of structurally diverse 4-difluoromethylated and perfluoroalkylated pyrazoles were obtained in moderate to good yields. The reactions proceeded smoothly under mild conditions with wide functional group tolerance.

中文翻译：

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一种多取代的4-二氟甲基和全氟烷基吡唑的合成方法

报道了一种通过全氟乙酰基重氮酸酯与酮的路易斯酸和碱共同介导的反应来合成多取代的4-二氟甲基和全氟烷基吡唑衍生物的方法。以中等至良好的产率获得了一系列结构多样的4-二氟甲基化和全氟烷基化的吡唑。反应在温和条件下顺利进行，具有宽泛的官能团耐受性。