<br>氧化石墨烯治疗诊断效应：基于体内演示的光热疗法和光动力疗法的结合,International Journal of Nanomedicine

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氧化石墨烯治疗诊断效应：基于体内演示的光热疗法和光动力疗法的结合
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2021-03-01 , DOI: 10.2147/ijn.s287415
Maria P Romero _{1,

2} , Hilde H Buzza ₁ , Mirian D Stringasci ₁ , Bianca M Estevão ₁ , Cecilia C C Silva ₃ , Marcelo A Pereira-da-Silva ₁ , Natalia M Inada ₁ , Vanderlei S Bagnato ₁

Affiliation

简介：癌症是全球第二大死亡原因，约占世界六分之一的死亡人数。因此，需要开发仅靶向肿瘤特定部位的有效抗肿瘤剂，以提高癌症诊断和治疗的效率，从而限制目前使用化疗剂所产生的不良全身副作用。在此背景下，由于氧化石墨烯（GO）独特的物理和化学性质，它引起了人们对癌症治疗生物医学的兴趣。

方法：在本研究中，我们报告了基于氧化石墨烯（nc-GO）且表面经过 PEG-叶酸、罗丹明 B 和吲哚菁绿修饰的纳米复合材料的体内应用。除了显示红色荧光光谱（罗丹明 B 作为荧光标记）外，还使用 nc-GO 进行体内实验，利用近红外光应用光动力疗法 (PDT) 和光热疗法 (PTT) 治疗小鼠艾氏肿瘤 (808纳米 1.8 瓦/平方厘米）。

结果：这项基于荧光图像的研究是在肿瘤中进行的，以获得肿瘤中 nc-GO 的最高浓度作为时间（腹腔注射后时间）的函数。获得的时间用于通过PDT/PTT有效治疗肿瘤。

讨论：当前的研究展示了一个成功使用 nc-GO 纳米复合材料作为治疗诊断纳米药物的例子，可同时进行体内荧光诊断以及组合 PDT-PTT 效应用于癌症治疗。

关键词：氧化石墨烯，光动力疗法，光热疗法，癌症治疗，纳米医学，基于氧化石墨烯的纳米复合材料，基于纳米粒子的药物输送系统，治疗诊断

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Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration

Introduction: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy.
Methods: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2).
Results: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT.
Discussion: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments.

Keywords: graphene oxide, photodynamic therapy, photothermal therapy, cancer treatments, nanomedicine, nanocomposites based on graphene oxide, nanoparticle-based drug delivery systems, theranostic

更新日期：2021-04-20

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