Unactivated Alkyl Halides in Transition-Metal-Catalyzed C–H Bond Alkylation,ACS Catalysis

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Unactivated Alkyl Halides in Transition-Metal-Catalyzed C–H Bond Alkylation
ACS Catalysis ( IF 11.3 ) Pub Date : 2021-02-28 , DOI: 10.1021/acscatal.0c05580
Shidheshwar B. Ankade _{1,

2} , Anand B. Shabade _{1,

2} , Vineeta Soni _{1,

2} , Benudhar Punji _{1,

2}

Affiliation

Alkylation represents an important organic transformation in molecular science to develop privileged alkylated arenes and heteroarenes. Especially, the direct C–H bond alkylation using unactivated alkyl halides is a straightforward and attractive approach from both the step-economy and chemoselectivity perspectives. Substantial progress has been made in the direct alkylation using primary, secondary, and tertiary alkyl halides along with the methylation and fluoroalkylation. This Review broadly summarizes the transition-metal-catalyzed alkylations of C–H bonds on various arenes and heteroarenes with unactivated alkyl halides until October 2020. On the basis of the substrates utilized for alkylation, the Review is divided into two major sections: alkylation of arenes and alkylation of heteroarenes.

中文翻译：

未活化的烷基卤化物在过渡金属催化的C–H键烷基化反应中

烷基化代表了分子科学中重要的有机转化，以发展特权的烷基化芳烃和杂芳烃。尤其是，从分步经济和化学选择性的角度来看，使用未活化的烷基卤化物直接进行C–H键烷基化是一种直接且有吸引力的方法。在使用伯，仲和叔烷基卤化物的直接烷基化以及甲基化和氟代烷基化方面已经取得了实质性进展。这篇综述广泛地总结了直到2020年10月，各种烃和杂芳烃上带有未活化烷基卤化物的C–H键的过渡金属催化烷基化。根据用于烷基化的底物，该综述分为两个主要部分：芳烃和杂芳烃的烷基化。

更新日期：2021-03-19

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