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Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface
ACS Omega ( IF 3.7 ) Pub Date : 2021-02-26 , DOI: 10.1021/acsomega.0c06327 Kazuhiko Ishihara 1 , Kyoko Fukazawa 1 , Vinay Sharma 2 , Shuang Liang 2 , Amanda Shows 2 , Daniel Chuck Dunbar 2 , Yang Zheng 3 , Junhao Ge 3 , Steve Zhang 3 , Ye Hong 3 , Xinfeng Shi 2 , James Yuliang Wu 2
ACS Omega ( IF 3.7 ) Pub Date : 2021-02-26 , DOI: 10.1021/acsomega.0c06327 Kazuhiko Ishihara 1 , Kyoko Fukazawa 1 , Vinay Sharma 2 , Shuang Liang 2 , Amanda Shows 2 , Daniel Chuck Dunbar 2 , Yang Zheng 3 , Junhao Ge 3 , Steve Zhang 3 , Ye Hong 3 , Xinfeng Shi 2 , James Yuliang Wu 2
Affiliation
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Inspired by the cell membrane surface as well as the ocular tissue, a novel and clinically applicable antifouling silicone hydrogel contact lens material was developed. The unique chemical and biological features on the surface on a silicone hydrogel base substrate were achieved by a cross-linked polymer layer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), which was considered important for optimal on-eye performance. The effects of the polymer layer on adsorption of biomolecules, such as lipid and proteins, and adhesion of cells and bacteria were evaluated and compared with several conventional silicone hydrogel contact lens materials. The MPC polymer layer provided significant resistance to lipid deposition as visually demonstrated by the three-dimensional confocal images of whole contact lenses. Also, fibroblast cell adhesion was decreased to a 1% level compared with that on the conventional silicone hydrogel contact lenses. The movement of the cells on the surface of the MPC polymer-modified lens material was greater compared with other silicone hydrogel contact lenses indicating that lubrication of the contact lenses on ocular tissue might be improved. The superior hydrophilic nature of the MPC polymer layer provides improved surface properties compared to the underlying silicone hydrogel base substrate.
中文翻译：
具有生物启发性的2-甲基丙烯酰氧基乙基磷酸胆碱聚合物表面的防污硅胶水凝胶隐形眼镜
受细胞膜表面和眼组织的启发，开发了一种新型且可在临床上应用的防污硅酮水凝胶隐形眼镜材料。有机硅水凝胶基础基材表面的独特化学和生物学特征是通过由2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）组成的交联聚合物层实现的，该层对获得最佳的眼用性能至关重要。评估了聚合物层对生物分子（例如脂质和蛋白质）的吸附以及细胞和细菌粘附的影响，并与几种常规的有机硅水凝胶隐形眼镜材料进行了比较。正如整个隐形眼镜的三维共聚焦图像所显示的那样，MPC聚合物层对脂类沉积具有显着的抵抗力。还，与传统的有机硅水凝胶隐形眼镜相比，成纤维细胞粘附力降低到1％。与其他有机硅水凝胶隐形眼镜相比，MPC聚合物改性的隐形眼镜材料表面细胞的运动更大，这表明隐形眼镜在眼组织上的润滑可能会得到改善。与下面的有机硅水凝胶基础基材相比，MPC聚合物层的优异亲水性可提供改善的表面性能。
更新日期：2021-03-16
中文翻译：
具有生物启发性的2-甲基丙烯酰氧基乙基磷酸胆碱聚合物表面的防污硅胶水凝胶隐形眼镜
受细胞膜表面和眼组织的启发，开发了一种新型且可在临床上应用的防污硅酮水凝胶隐形眼镜材料。有机硅水凝胶基础基材表面的独特化学和生物学特征是通过由2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）组成的交联聚合物层实现的，该层对获得最佳的眼用性能至关重要。评估了聚合物层对生物分子（例如脂质和蛋白质）的吸附以及细胞和细菌粘附的影响，并与几种常规的有机硅水凝胶隐形眼镜材料进行了比较。正如整个隐形眼镜的三维共聚焦图像所显示的那样，MPC聚合物层对脂类沉积具有显着的抵抗力。还，与传统的有机硅水凝胶隐形眼镜相比，成纤维细胞粘附力降低到1％。与其他有机硅水凝胶隐形眼镜相比，MPC聚合物改性的隐形眼镜材料表面细胞的运动更大，这表明隐形眼镜在眼组织上的润滑可能会得到改善。与下面的有机硅水凝胶基础基材相比，MPC聚合物层的优异亲水性可提供改善的表面性能。
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