Metastable and rarely reported GO warped tetragonal phase t-lanthanum vanadate nanocomposites (GO@LaVO₄-NCs) are reported for the sensitive electrochemical determination of antifungal drug Clioquinol (CQ). The hydrothermal method was adopted for synthesis of GO@LaVO₄-NCs. The electrochemical performance of CQ was examined using cyclic voltammetry (CV) and differential plus voltammetry (DPV) at GO@LaVO₄-NCs modified glassy carbon electrode (GCE). The electrocatalytic oxidation of CQ at the GO@LaVO₄-NCs/GCE shows the highest anodic peak current at a potential of +0.51 V vs. Ag/AgCl. The proposed sensor provides excellent sensitivity of 4.1894 μA μM⁻¹ cm⁻², a very low detection limit (LOD) of 2.44 nM, and a wide range of 25 nM to 438.52 μM towards CQ detection. Finally, the detection of CQ in biological media was successfully done using the GO@LaVO₄-NCs/GCE and possesses recoveries of 94.67–98.0%.

Graphical abstract

中文翻译：

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氧化石墨烯扭曲的四方钒酸镧（GO@LaVO 4 ）纳米复合材料的电催化评价用于伏安法检测抗真菌和抗原生动物药物（氯碘羟喹）

亚稳态和很少报道的 GO 扭曲的四方相 t-钒酸镧纳米复合材料 (GO@LaVO ₄ -NCs) 被报道用于抗真菌药物氯碘喹 (CQ) 的灵敏电化学测定。采用水热法合成GO@LaVO ₄ -NCs。使用循环伏安法 (CV) 和微分加伏安法 (DPV) 在 GO@LaVO ₄ -NCs 修饰的玻碳电极 (GCE) 上检测 CQ 的电化学性能。CQ 在 GO@LaVO ₄ -NCs/GCE 上的电催化氧化在+0.51 V 与 Ag/AgCl 电位下显示出最高的阳极峰值电流。所提出的传感器提供了 4.1894 μA μM ^-1  cm ^{-2 的}出色灵敏度，2.44 nM 的极低检测限 (LOD)，以及 25 nM 至 438.52 μM 的宽范围，可用于 CQ 检测。最后，使用 GO@LaVO ₄ -NCs/GCE成功完成了生物介质中 CQ 的检测，回收率为 94.67-98.0%。

图形概要