Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αβ T lymphocytes in untreated celiac disease,European Journal of Immunology

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Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αβ T lymphocytes in untreated celiac disease
European Journal of Immunology ( IF 4.5 ) Pub Date : 2021-02-09 , DOI: 10.1002/eji.202048974
Linn M Eggesbø ₁ , Louise F Risnes _{1,

2} , Ralf S Neumann ₁ , Knut E A Lundin _{1,

3} , Asbjørn Christophersen ₁ , Ludvig M Sollid _{1,

2}

Affiliation

We compared the αβ T-cell receptor repertoires of CD8⁺ αβ intraepithelial lymphocytes from celiac disease patients and healthy subjects by single-cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.

中文翻译：

单细胞 TCR 谱分析揭示了未经治疗的乳糜泻中人上皮内 CD8+ αβ T 淋巴细胞的高度多克隆组成

我们通过单细胞测序比较了来自乳糜泻患者和健康受试者的 CD8 ⁺ αβ 上皮内淋巴细胞的 αβ T 细胞受体库。我们证明，与接受治疗的患者和健康受试者观察到的相比，未治疗的乳糜泻患者的曲目更加多克隆和更加多样化。

更新日期：2021-02-09

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