口服姜黄双去甲氧基姜黄素和印楝柠檬苦素可改善糖尿病大鼠血清淀粉酶和葡萄糖水平,Journal of Food Biochemistry

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口服姜黄双去甲氧基姜黄素和印楝柠檬苦素可改善糖尿病大鼠血清淀粉酶和葡萄糖水平
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-02-26 , DOI: 10.1111/jfbc.13674
Sudha Ramkumar ₁ , H V Thulasiram ₂ , Ameeta RaviKumar ₁

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Curcuma longa和Azadirachta indica传统上用于印度美食和阿育吠陀医学，作为抗糖尿病的营养品。粗C . longa异丙醇提取物，双去甲氧基姜黄素 (BDMC)，从C中纯化的生物活性成分。 longa和柠檬苦素 azadiradione, gedunin 来自A。籼稻，能够在体外独立抑制抗糖尿病靶点人胰腺α-淀粉酶。然而，没有关于它们在动物模型中的体内功效的报道。因此，这些口服人胰腺α-淀粉酶抑制剂的抗糖尿病作用是在链脲佐菌素诱导的 Sprague-Dawley 大鼠上进行的。最初，正常大鼠用玉米油（5 ml/kg）中的试验化合物（10-100 mg/kg 体重）进行治疗，由于在这些剂量下没有观察到致死性，因此以最低浓度进行了进一步研究10毫克/公斤体重。曲线下面积 (AUC) 的减少表明这些化合物在喂食淀粉的糖尿病大鼠中具有降糖作用。功效研究显示体重、血糖水平、血清淀粉酶、果糖胺水平以及其他与糖尿病相关的肝肾功能血清参数。因此，在体内条件下，BDMC 和柠檬苦素对 α-淀粉酶活性的抑制证实了它是导致血糖水平降低的作用机制之一。

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Improvement in serum amylase and glucose levels in diabetic rats on oral administration of bisdemethoxycurcumin from Curcuma longa and limonoids from Azadirachta indica

Curcuma longa and Azadirachta indica are traditionally used in Indian cuisine and Ayurvedic medicine as nutraceuticals against diabetes. The crude C. longa isopropanol extract, bisdemethoxycurcumin (BDMC), the purified bioactive component from C. longa, and limonoids azadiradione, gedunin from A. indica, are able to inhibit in vitro the antidiabetic target human pancreatic α‐amylase independently. However, no reports on their in vivo efficacy in animal models exist. Thus, the antidiabetic effect of these orally administered human pancreatic α‐amylase inhibitors was performed on streptozotocin‐induced Sprague–Dawley rats. Initially, the normal rats were treated with test compounds (10–100 mg/kg of body weight) in corn oil (5 ml/kg), and as no lethality was observed in these doses, further studies were carried out with lowest concentration of 10 mg/kg of body weight. A reduction in area under curve (AUC) suggested glucose‐lowering effect of these compounds in starch fed diabetic rats. The efficacy study showed a significant improvement in body weight, blood glucose levels, serum amylase, and fructosamine levels as well in other serum parameters associated with diabetes with respect to liver and renal functions. Hence, under in vivo conditions, inhibition of α‐amylase activity by BDMC and limonoids affirms it as one of the mechanisms of action resulting in reduction of blood glucose levels.

更新日期：2021-04-22

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