两种脑成像表型的跨性别转变及其与同性性行为多基因评分的关系：一项针对来自英国生物银行的 18,645 名个体的研究,Human Brain Mapping

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两种脑成像表型的跨性别转变及其与同性性行为多基因评分的关系：一项针对来自英国生物银行的 18,645 名个体的研究
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-02-26 , DOI: 10.1002/hbm.25370
Christoph Abé ₁ , Alexander Lebedev ₁ , Ruyue Zhang ₂ , Lina Jonsson _{3,

4} , Sarah E Bergen ₂ , Martin Ingvar ₁ , Mikael Landén _{2,

3} , Qazi Rahman ₅

Affiliation

遗传和荷尔蒙因素被认为会影响人类的性取向。先前的研究提出了与性取向相关的大脑差异，并且这些差异遵循跨性别转移模式。然而，性取向的神经生物学相关性以及遗传因素与大脑结构变异的关系在很大程度上仍未得到探索。使用最大的同性性行为（SSB）神经影像遗传学数据集（n= 18,645)，我们对来自两种成像模式的磁共振成像数据采用数据驱动的多元分类算法 (PLS)，以提取与性别相关的大脑协方差模式。通过对潜在变量的分析，我们测试了这种模式中与 SSB 相关的跨性别转变。使用基因型数据，计算反映 SSB 遗传倾向的多基因评分并测试与神经影像学结果的关联。对男性和女性进行分类的重要模式在非异性恋者中不太明显。主要在非异性恋女性中，以潜在变量为代表的多元大脑模式向异性转移。补充单变量分析揭示了男性和女性的区域特异性 SSB 相关差异。SSB 的多基因评分与枕外侧和颞枕皮质的体积相关。目前的大规模研究证明了 SSB 的多变量神经解剖学相关性，并初步表明与 SSB 相关的遗传因素可能导致某些大脑结构的结构变异。这些发现支持了人类性行为差异的神经生物学基础。

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Cross‐sex shifts in two brain imaging phenotypes and their relation to polygenic scores for same‐sex sexual behavior: A study of 18,645 individuals from the UK Biobank

Genetic and hormonal factors have been suggested to influence human sexual orientation. Previous studied proposed brain differences related to sexual orientation and that these follow cross‐sex shifted patterns. However, the neurobiological correlates of sexual orientation and how genetic factors relate to brain structural variation remains largely unexplored. Using the largest neuroimaging‐genetics dataset available on same‐sex sexual behavior (SSB) (n = 18,645), we employed a data‐driven multivariate classification algorithm (PLS) on magnetic resonance imaging data from two imaging modalities to extract brain covariance patterns related to sex. Through analyses of latent variables, we tested for SSB‐related cross‐sex shifts in such patterns. Using genotype data, polygenic scores reflecting the genetic predisposition for SSB were computed and tested for associations with neuroimaging outcomes. Patterns important for classifying between males and females were less pronounced in non‐heterosexuals. Predominantly in non‐heterosexual females, multivariate brain patterns as represented by latent variables were shifted toward the opposite sex. Complementary univariate analyses revealed region specific SSB‐related differences in both males and females. Polygenic scores for SSB were associated with volume of lateral occipital and temporo‐occipital cortices. The present large‐scale study demonstrates multivariate neuroanatomical correlates of SSB, and tentatively suggests that genetic factors related to SSB may contribute to structural variation in certain brain structures. These findings support a neurobiological basis to the differences in human sexuality.

更新日期：2021-04-15

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