Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization. Therefore, the functionalized double-network hydrogel should be a potential candidate as wound dressings

有效的伤口敷料对预防感染和促进伤口愈合具有重要意义。然而，大多数现有的水凝胶敷料在机械性能，生物活性或通用性方面均不足。在这里，我们介绍了一种由胶原蛋白肽官能化的羧甲基壳聚糖（CS）和氧化的甲基丙烯酸海藻酸钠（SA）组成的双网络交联的多糖基水凝胶。该水凝胶具有相互连接的多孔形态，合适的溶胀比，优异的机械性能和良好的生物相容性。同时，体内使用小鼠全厚度皮肤缺损模型的研究表明，双网络CS / SA水凝胶可通过调节炎症过程，促进胶原蛋白沉积和改善血管形成来显着加速伤口愈合。因此，功能化的双网络水凝胶应作为伤口敷料的潜在候选者