Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment,Nanoscale

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Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment
Nanoscale ( IF 5.8 ) Pub Date : 2021-2-19 , DOI: 10.1039/d0nr08757b
Qifang Chen _{1,

2,

3,

4,

5} , Xianbin Ma _{4,

5,

6,

7} , Li Xie _{1,

2,

3,

4,

5} , Wenjie Chen _{1,

2,

3,

4,

5} , Zhigang Xu _{4,

5,

6,

7} , Erqun Song _{1,

2,

3,

4,

5} , Xiaokang Zhu _{1,

2,

3,

4,

5} , Yang Song _{1,

2,

3,

4,

5}

Affiliation

Ferroptosis therapy, which applies ferroptotic inducers to produce lethal lipid peroxidation and induce the death of tumor cells, is regarded as a promising therapeutic strategy for cancer treatment. However, there is still a challenge regarding how to increase reactive oxygen species (ROS) accumulation in the tumor microenvironment (TME) to enhance antitumor efficacy. Herein, we designed a nanosystem coated with the FDA approved poly(lactic-co-glycolic acid) (PLGA) containing ferrous ferric oxide (Fe₃O₄) and chlorin E6 (Ce6) for synergistic ferroptosis-photodynamic anticancer therapy. The Fe₃O₄-PLGA-Ce6 nanosystem can dissociate in the acidic TME to release ferrous/ferric ions and Ce6. Then, the Fenton reaction between the released ferrous/ferric ions and intracellular excess hydrogen peroxide can occur to produce hydroxyl radicals (˙OH) and induce tumor cell ferroptosis. The released Ce6 can increase the generation and accumulation of ROS under laser irradiation to offer photodynamic therapy, which can boost ferroptosis in 4T1 cells. Moreover, magnetic monodisperse Fe₃O₄ loading provides excellent T₂-weighted magnetic resonance imaging (MRI) properties. The Fe₃O₄-PLGA-Ce6 nanosystem possesses MRI ability and highly efficient tumor suppression with high biocompatibility in vivo due to the synergism of photodynamic and ferroptosis antitumor therapies.

中文翻译：

铁基纳米颗粒，用于MR成像引导的肥大症，结合光动力疗法以增强癌症治疗

施肥性疗法，应用施肥性诱导剂产生致命的脂质过氧化作用并诱导肿瘤细胞死亡，被认为是一种有前途的癌症治疗策略。然而，关于如何增加肿瘤微环境（TME）中活性氧（ROS）的积累以增强抗肿瘤功效仍存在挑战。在本文中，我们设计了涂有FDA一个纳米系统批准聚（乳酸-共含亚铁氧化铁-glycolic乙酸）（PLGA）（铁₃ ø ₄的协同ferroptosis光动力抗癌疗法）和二氢卟酚e6（的Ce6）。铁₃ O ₄-PLGA-Ce6纳米系统可在酸性TME中解离以释放亚铁/铁离子和Ce6。然后，释放的亚铁/铁离子与细胞内过量的过氧化氢之间的芬顿反应可能发生，从而产生羟基自由基（˙OH），并诱导肿瘤细胞肥大。释放的Ce6可以增加激光照射下ROS的产生和积累，从而提供光动力疗法，从而可以促进4T1细胞中的肥大症。此外，单分散磁性Fe ₃ O _4的负载提供了出色的T ₂加权磁共振成像（MRI）性能。Fe ₃ O ₄ -PLGA-Ce6纳米系统具有核磁共振成像能力和高效的肿瘤抑制作用，具有高生物相容性在体内由于光动力和铁质增生抗肿瘤治疗的协同作用。

更新日期：2021-02-24

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