The Castagnoli-Cushman reaction of various azaindole dicarboxylic acids with imines using acetic anhydride as a dehydrating agent was significantly accelerated by microwave irradiation. The reaction conditions offer a convenient preparation of novel 6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines in moderate to good yields with good trans stereoselectivity.

中文翻译：

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微波加速Castagnoli-Cushman反应：新型6,7,8,9-四氢吡啶并[3'，2'：4,5]吡咯并[1,2- a ]吡嗪的合成

使用乙酸酐作为脱水剂，各种氮杂吲哚二羧酸与亚胺的Castagnoli-Cushman反应可通过微波辐射显着加速。反应条件提供了方便的制备新型6,7,8,9-四氢吡啶并[3'，2'：4,5]吡咯并[1,2- a ]吡嗪的良好收率和良好的反式立体选择性。