A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.

中文翻译：

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选择性二氟甲基化合成二氟甲基取代的喹唑啉

通过使用市售的溴二氟乙酸乙酯作为二氟卡宾前体，可以实现喹唑啉的高选择性二氟甲基化，从而以高达83％的收率提供相应的二氟甲基取代的喹唑啉衍生物。