Superficial macular vessel density in eyes with mild, moderate, and severe primary open-angle glaucoma,Graefe's Archive for Clinical and Experimental Ophthalmology

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Superficial macular vessel density in eyes with mild, moderate, and severe primary open-angle glaucoma
Graefe's Archive for Clinical and Experimental Ophthalmology ( IF 2.4 ) Pub Date : 2021-02-22 , DOI: 10.1007/s00417-021-05120-4
Yanjiao Huo ₁ , Ravi Thomas _{2,

3,

4} , Yan Guo ₁ , Wei Zhang ₁ , Lei Li ₁ , Kai Cao ₁ , Huaizhou Wang ₁ , Ningli Wang _{1,

4}

Affiliation

Purpose

The aim of this study is to report changes in and associations of macular vessel density (VD) and perfusion density (PD) using optical coherence tomography angiography (OCTA) in mild, moderate, and severe open-angle glaucoma.

Methods

One hundred thirty-three patients with open-angle glaucoma (133 eyes: 47 mild, 33 moderate, and 53 severe glaucoma) and 73 normal subjects (right eyes) were included in this cross-sectional study. All subjects underwent Cirrus OCTA measurements. One-way analysis of variance (ANOVA) was used to compare macular VD and PD between the controls and mild, moderate, and severe glaucoma groups. Multiple linear regression was performed with OCTA parameters as the predicted variable and age, gender, spherical equivalent (SE), intraocular pressure (IOP), mean deviation (MD), signal strength (SS), and mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness as the predictor variables.

Results

The total area of VD showed significant differences between the controls vs. mild (p < 0.001) and moderate vs. severe glaucoma (p = 0.003); no significant difference was found between mild and moderate glaucoma (p = 1.000). Macular VD was associated with age (β = −0.02, p = 0.003), MD (β = 0.04, p = 0.001), SS (β = 1.43, p < 0.001), and mGCIPL thickness (β = 0.04, p = 0.002) but not with gender, SE, and IOP (all p > 0.05).

Conclusions

Macular microcirculation declined significantly in mild and severe glaucoma. No significant difference was found between mild and moderate glaucoma. Decrease macular VD was independently associated with age, severe MD, lower SS, and thinner mGCIPL thickness.

中文翻译：

轻度、中度和重度原发性开角型青光眼眼的浅表黄斑血管密度

目的

本研究的目的是在轻度、中度和重度开角型青光眼中使用光学相干断层扫描血管造影 (OCTA) 报告黄斑血管密度 (VD) 和灌注密度 (PD) 的变化和关联。

方法

133 名开角型青光眼患者（133 只眼：47 只轻度、33 只中度和53 只重度青光眼）和 73 名正常人（右眼）被纳入这项横断面研究。所有受试者都接受了 Cirrus OCTA 测量。使用单因素方差分析 (ANOVA) 来比较对照组与轻度、中度和重度青光眼组之间的黄斑部 VD 和 PD。以 OCTA 参数作为预测变量和年龄、性别、球面当量 (SE)、眼压 (IOP)、平均偏差 (MD)、信号强度 (SS) 和平均黄斑神经节细胞 - 内丛状层进行多元线性回归(mGCIPL) 厚度作为预测变量。

结果

VD 的总面积在对照组与轻度 ( p < 0.001) 和中度与重度青光眼 ( p = 0.003)之间显示出显着差异；轻度和中度青光眼之间没有发现显着差异（p = 1.000）。黄斑部 VD 与年龄 ( β = -0.02, p = 0.003)、MD ( β = 0.04, p = 0.001)、SS ( β = 1.43, p < 0.001) 和 mGCIPL 厚度 ( β = 0.04, p = 0.002) 相关) 但与性别、SE 和 IOP 无关（所有p > 0.05）。