Significance: Dermal fibroblasts are the major cell type in the skin's dermal layer. These cells originate from distinct locations of the embryo and reside in unique niches in the dermis. Different dermal fibroblasts exhibit distinct roles in skin development, homeostasis, and wound healing. Therefore, these cells are becoming attractive candidates for cell-based therapies in wound healing.

中文翻译：

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真皮成纤维细胞异质性及其对皮肤修复和再生的贡献

意义：真皮成纤维细胞是皮肤真皮层中的主要细胞类型。这些细胞起源于胚胎的不同位置，并存在于真皮中独特的壁龛中。不同的真皮成纤维细胞在皮肤发育、体内平衡和伤口愈合中表现出不同的作用。因此，这些细胞正在成为伤口愈合中基于细胞的疗法的有吸引力的候选者。