The title compound, diethyl [(4-{(9H-carbazol-9-yl)methyl}-1H-1,2,3-triazol-1-yl)(benzamido)methyl]phosphonate, was synthesized with excellent yield and high regioselectivity through 1,3-dipolar cycloaddition reaction between the α-azido diethyl amino methylphosphonate and the heterocyclic alkyne, 9-(prop-2-yn-1-yl)-9H-carbazole. The cyclization reaction by “click chemistry” was carried out in a water/ethanol solvent mixture (50/50), in the presence of copper sulfate pentahydrate and catalytic sodium ascorbate. The characterization of the structure of the resulting 1,4-regioisomer was performed by 1D and 2D-NMR experiments, infrared spectroscopy, and elemental analysis.

中文翻译：

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[（4-{（9H-咔唑-9-基）甲基} -1H-1,2,3-三唑-1-基）（苯甲酰胺基）甲基]二膦酸酯

合成标题化合物[（4-{（9H-咔唑-9-基）甲基} -1H-1,2,3-三唑-1-基）（苯甲酰胺基）甲基]膦酸二乙酯，收率高，收率高。通过α-叠氮基二乙基氨基甲基膦酸酯与杂环炔烃9-（prop-2-yn-1-yl）-9H-咔唑之间的1,3-偶极环加成反应实现区域选择性。通过“点击化学”的环化反应在水/乙醇溶剂混合物（50/50）中，在五水合硫酸铜和催化性抗坏血酸钠的存在下进行。通过1D和2D-NMR实验，红外光谱和元素分析对所得的1,4-区域异构体的结构进行表征。