With the availability of new technologies, the number of subjects undergoing medical and cosmetic interventions is increasing. Many procedures (e.g., ablative fractional laser treatment) resulting in superficial/minor wounds require appropriate aftercare to prevent complications in wound healing and poor cosmetic outcome. We review the published evidence of the usefulness of topical dexpanthenol in postprocedure wound healing and the associated mechanisms of action at the molecular level. A search in the PubMed and Embase databases was performed to query the terms dexpanthenol, panthenol, superficial wound, minor wound, wound healing, skin repair, and postprocedure. Search results were categorized as clinical trials and in vitro studies. In vitro and clinical studies provided evidence that topically applied dexpanthenol promotes superficial and postprocedure wound healing. Latest findings confirmed that dexpanthenol upregulates genes that are critical for the healing process. The gene expression data are of clinical relevance as evidenced by prospective clinical studies indicating that topical dexpanthenol accelerates wound healing with rapid re-epithelialization and restoration of skin barrier function following skin injury. It can therefore be inferred that topical dexpanthenol represents an appropriate and state-of-the-art treatment option for superficial postprocedure wounds, especially when applied early after the superficial skin damage.

中文翻译：

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医学和美容干预后伤口愈合中的地芬太尼（术后伤口愈合）

随着新技术的普及，接受医学和美容干预的受试者数量正在增加。导致浅表/小伤口的许多程序（例如，消融分段激光治疗）都需要进行适当的后期护理，以防止伤口愈合中的并发症和不良的美容效果。我们审查了局部用地芬太尼在术后伤口愈合中的作用以及在分子水平上相关作用机制的已发表证据。在PubMed和Embase数据库中进行了搜索，以查询术语dexpanthenol，泛醇，浅表伤口，小伤口，伤口愈合，皮肤修复和手术后。搜索结果分为临床试验和体外研究。体外和临床研究提供了证据，表明局部应用右泛醇可促进浅表和术后伤口愈合。最新发现证实右旋泛醇上调了对愈合过程至关重要的基因。该基因表达数据具有临床相关性，如前瞻性临床研究所证明的那样，表明局部右旋泛醇可在皮肤损伤后迅速重新上皮化并恢复皮肤屏障功能，从而加速伤口愈合。因此，可以推断出局部地芬太尼代表了浅表性手术后伤口的合适且最新的治疗选择，尤其是在浅表皮肤损伤后早期使用时。该基因表达数据具有临床相关性，如前瞻性临床研究所证明的那样，表明局部右旋泛醇可在皮肤损伤后迅速重新上皮化并恢复皮肤屏障功能，从而加速伤口愈合。因此，可以推断出局部地芬太尼代表了浅表性手术后伤口的合适且最新的治疗选择，尤其是在浅表皮肤损伤后早期使用时。该基因表达数据具有临床相关性，如前瞻性临床研究所证明的那样，表明局部右旋泛醇可在皮肤损伤后迅速重新上皮化并恢复皮肤屏障功能，从而加速伤口愈合。因此，可以推断出局部地芬太尼代表了浅表性手术后伤口的合适且最新的治疗选择，尤其是在浅表皮肤损伤后早期使用时。